A Central Role for Ly49 Receptors in NK Cell Memory.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
20
02
2020
accepted:
06
04
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
9
3
2021
Statut:
ppublish
Résumé
In the past decade, the study of NK cells was transformed by the discovery of three ways these "innate" immune cells display adaptive immune behavior, including the ability to form long-lasting, Ag-specific memories of a wide variety of immunogens. In this review, we examine these types of NK cell memory, highlighting their unique features and underlying similarities. We explore those similarities in depth, focusing on the role that Ly49 receptors play in various types of NK cell memory. From this Ly49 dependency, we will build a model by which we understand the three types of NK cell memory as aspects of what is ultimately the same adaptive immune process, rather than separate facets of NK cell biology. We hope that a defined model for NK cell memory will empower collaboration between researchers of these three fields to further our understanding of this surprising and clinically promising immune response.
Identifiants
pubmed: 32423924
pii: 204/11/2867
doi: 10.4049/jimmunol.2000196
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
NK Cell Lectin-Like Receptor Subfamily A
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2867-2875Subventions
Organisme : CIHR
ID : MOP-155906
Pays : Canada
Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.