Quantifying the Influence of Wedge Pressure, Age, and Heart Rate on the Systolic Thresholds for Detection of Pulmonary Hypertension.


Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
02 06 2020
Historique:
pubmed: 19 5 2020
medline: 11 3 2021
entrez: 19 5 2020
Statut: ppublish

Résumé

Background The strong linear relation between mean (MPAP) and systolic (SPAP) pulmonary arterial pressure (eg, SPAP=1.62×MPAP) has been mainly reported in precapillary pulmonary hypertension. This study sought to quantify the influence of pulmonary arterial wedge pressure (PAWP), heart rate, and age on the MPAP-SPAP relation. Methods and Results An allometric equation relating invasive MPAP and SPAP was developed in 1135 patients with pulmonary arterial hypertension, advanced lung disease, chronic thromboembolic pulmonary hypertension, or left heart failure. The equation was validated in 60 885 patients from the United Network for Organ Sharing (UNOS) database referred for heart and/or lung transplant. The MPAP/SPAP longitudinal stability was assessed in pulmonary arterial hypertension with repeated right heart catheterization. The equation obtained was SPAP=1.39×MPAP×PAWP

Identifiants

pubmed: 32419583
doi: 10.1161/JAHA.119.016265
pmc: PMC7428994
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Validation Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

e016265

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Auteurs

Myriam Amsallem (M)

Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA.
Stanford Cardiovascular Institute Stanford University School of Medicine Stanford CA.

Ryan J Tedford (RJ)

Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC.

Andre Denault (A)

Department of Anesthesiology and Division of Critical Care Montreal Heart Institute Université de Montréal Quebec Canada.

Andrew J Sweatt (AJ)

Division of Pulmonary and Critical Care Medicine Stanford University School of Medicine Stanford CA.
Vera Moulton Wall Center for Pulmonary Disease at Stanford University Stanford CA.

Julien Guihaire (J)

Research and Innovation Unit INSERM U999 DHU TORINO Paris Sud University Marie Lannelongue Hospital Le Plessis Robinson France.

Kristofer Hedman (K)

Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA.
Department of Medical and Health Sciences Linköping University Linköping Sweden.

Shadi Peighambari (S)

Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA.

Juyong Brian Kim (JB)

Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA.
Stanford Cardiovascular Institute Stanford University School of Medicine Stanford CA.

Xiao Li (X)

Department of Genetics Stanford University School of Medicine Stanford CA.

Robert J H Miller (RJH)

Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA.

Olaf Mercier (O)

Research and Innovation Unit INSERM U999 DHU TORINO Paris Sud University Marie Lannelongue Hospital Le Plessis Robinson France.

Elie Fadel (E)

Research and Innovation Unit INSERM U999 DHU TORINO Paris Sud University Marie Lannelongue Hospital Le Plessis Robinson France.

Roham Zamanian (R)

Division of Pulmonary and Critical Care Medicine Stanford University School of Medicine Stanford CA.
Vera Moulton Wall Center for Pulmonary Disease at Stanford University Stanford CA.

Francois Haddad (F)

Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA.
Stanford Cardiovascular Institute Stanford University School of Medicine Stanford CA.

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Classifications MeSH