Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.
Age Factors
Aged
Aged, 80 and over
Apolipoproteins E
/ genetics
Biomarkers
/ analysis
Cognition
Databases, Factual
Female
Genotype
Hippocampus
/ anatomy & histology
Humans
Linear Models
Male
Middle Aged
Neuroimaging
/ statistics & numerical data
Organ Size
Parenchymal Tissue
/ anatomy & histology
Reference Values
Sex Factors
Alzheimer’s disease
Apolipoprotein E ϵ4
Atrophy
Brain
Healthy aging
Hippocampal parenchymal fraction
Hippocampal volumetric integrity
Hippocampus
MRI
Mild cognitive impairment
Neurodegeneration
Sex
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 07 2020
30 07 2020
Historique:
received:
13
01
2020
revised:
24
03
2020
accepted:
15
04
2020
pubmed:
18
5
2020
medline:
1
12
2020
entrez:
17
5
2020
Statut:
ppublish
Résumé
Early detection of Alzheimer's disease (AD) is important for timely interventions and developing new treatments. Hippocampus atrophy is an early biomarker of AD. The hippocampal parenchymal fraction (HPF) is a promising measure of hippocampal structural integrity computed from structural MRI. It is important to characterize the dependence of HPF on covariates such as age and sex in the normal population to enhance its utility as a disease biomarker. We measured the HPF in 4239 structural MRI scans from 340 cognitively normal (CN) subjects aged 59-89 years from the AD Neuroimaging Initiative database, and studied its dependence on age, sex, apolipoprotein E (APOE) genotype, brain hemisphere, intracranial volume (ICV), and education using a linear mixed-effects model. In this CN cohort, HPF was inversely associated with ICV; was greater on the right hemisphere compared to left in both sexes with the degree of right > left asymmetry being slightly more pronounced in men; declined quadratically with age and faster in APOE ϵ4 carriers compared to non-carriers; and was significantly associated with cognitive ability. Consideration of HPF as an AD biomarker should be in conjunction with other subject attributes that are shown in this research to influence HPF levels in CN older individuals.
Identifiants
pubmed: 32416384
pii: S0925-4927(20)30079-2
doi: 10.1016/j.pscychresns.2020.111107
pii:
doi:
Substances chimiques
ApoE protein, human
0
Apolipoproteins E
0
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
111107Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.