Successful intervention for overwhelming postsplenectomy infection caused by non-vaccine pneumococcal serotype 23A.
Journal
Oxford medical case reports
ISSN: 2053-8855
Titre abrégé: Oxf Med Case Reports
Pays: England
ID NLM: 101642070
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
15
12
2019
revised:
27
02
2020
accepted:
05
03
2020
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
13
5
2020
Statut:
epublish
Résumé
The spleen plays an important role in the body's immune defense against invasive infections, particularly those caused by encapsulated bacteria. Encapsulated bacterial infection in asplenic patients is a medical emergency called overwhelming postsplenectomy infection (OPSI) and has a mortality rate of 50-70%. Here, we report the case of a 51-year-old Asian man who complained of emesis and diarrhea as primary symptoms. He rapidly progressed to coma and was eventually diagnosed with OPSI (pyogenic ventriculitis/spondylitis) caused by non-vaccine pneumococcal serotype 23A. Aggressive management, including empiric antibiotic therapy, a staircase approach for intracranial pressure-targeted therapy and laminectomy/laminoplasty, resulted in a good recovery. Our report highlights that non-vaccine pneumococcal serotypes can cause disease in vaccinated patients.
Identifiants
pubmed: 32395252
doi: 10.1093/omcr/omaa018
pii: omaa018
pmc: PMC7202049
doi:
Types de publication
Journal Article
Langues
eng
Pagination
omaa018Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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