Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables.
biomarkers
disease states
drug development
individualized dosing
pharmacoeconomics
pharmacokinetics/pharmacodynamics
precision dosing
therapeutic index
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
11
2019
accepted:
19
03
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
The administered dose of a drug modulates whether patients will experience optimal effectiveness, toxicity including death, or no effect at all. Dosing is particularly important for diseases and/or drugs where the drug can decrease severe morbidity or prolong life. Likewise, dosing is important where the drug can cause death or severe morbidity. Since we believe there are many examples where more precise dosing could benefit patients, it is worthwhile to consider how to prioritize drug-disease targets. One key consideration is the quality of information available from which more precise dosing recommendations can be constructed. When a new more precise dosing scheme is created and differs significantly from the approved label, it is important to consider the level of proof necessary to either change the label and/or change clinical practice. The cost and effort needed to provide this proof should also be considered in prioritizing drug-disease precision dosing targets. Although precision dosing is being promoted and has great promise, it is underutilized in many drugs and disease states. Therefore, we believe it is important to consider how more precise dosing is going to be delivered to high priority patients in a timely manner. If better dosing schemes do not change clinical practice resulting in better patient outcomes, then what is the use? This review paper discusses variables to consider when prioritizing precision dosing candidates while highlighting key examples of precision dosing that have been successfully used to improve patient care.
Identifiants
pubmed: 32390828
doi: 10.3389/fphar.2020.00420
pmc: PMC7188913
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
420Subventions
Organisme : NICHD NIH HHS
ID : K23 HD083465
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD096435
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM086330
Pays : United States
Informations de copyright
Copyright © 2020 Tyson, Park, Powell, Patterson, Weiner, Watkins and Gonzalez.
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