Subregional statistical shape modelling identifies lesser trochanter size as a possible risk factor for radiographic hip osteoarthritis, a cross-sectional analysis from the Osteoporotic Fractures in Men Study.

Absorptiometry, Photon Acetabulum / anatomy & histology Aged Aged, 80 and over Cross-Sectional Studies Femur / anatomy & histology Humans Imaging, Three-Dimensional Male Middle Aged Models, Statistical Osteoarthritis, Hip / diagnostic imaging Radiography Risk Factors Tomography, X-Ray Computed
Epidemiology Hip shape Osteoarthritis Statistical shape modelling

Journal

Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697

Informations de publication

Date de publication:
08 2020
Historique:
received: 22 11 2019
revised: 17 03 2020
accepted: 27 04 2020
pubmed: 11 5 2020
medline: 27 7 2021
entrez: 11 5 2020
Statut: ppublish

Résumé

Statistical shape modelling (SSM) of hip dual-energy X-ray absorptiometry (DXA) scans has identified relationships between hip shape and radiographic hip OA (rHOA). We aimed to further elucidate shape characteristics related to rHOA by focusing on subregions identified from whole-hip shape models. SSM was applied to hip DXAs obtained in the Osteoporotic Fractures in Men Study. Whole-hip shape modes (HSMs) associated with rHOA were combined to form a composite at-risk-shape. Subsequently, subregional HSMs (cam-type and lesser trochanter modes) were built, and associations with rHOA were examined by logistic regression. Subregional HSMs were further characterised, by examining associations with 3D-HSMs derived from concurrent hip CT scans. 4,098 participants were identified with hip DXAs and radiographs. Composite shapes from whole-hip HSMs revealed that lesser trochanter size and cam-type femoral head are related to rHOA. From sub-regional models, lesser trochanter mode (LTM)1 [OR 0.74; 95%CI 0.63.0.87] and cam-type mode (CTM)3 [OR 1.27; 1.13.1.42] were associated with rHOA, associations being similar to those for whole hip HSMs. 515 MrOS participants had hip DXAs and 3D-HSMs derived from hip CT scans. LTM1 was associated with 3D-HSMs that also represented a larger lesser trochanter [3D-HSM7 (beta (β)-0.23;-0.33,-0.14) and 3D-HSM9 (β0.36; 0.27.0.45)], and CTM3 with 3D-HSMs describing cam morphology [3D-HSM3 (β-0.16;-0.25,-0.07) and 3D-HSM6 (β 0.19; 0.10.0.28)]. Subregional SSM of hip DXA scans suggested larger lesser trochanter and cam morphology underlie associations between overall hip shape and rHOA. 3D hip modelling suggests our subregional SSMs represent true anatomical variations in hip shape, warranting further investigation.

Identifiants

DOI: 10.1016/j.joca.2020.04.011 PMID: 32387760 PMC: PMC7387228
pubmed: 32387760
pii: S1063-4584(20)30989-4
doi: 10.1016/j.joca.2020.04.011
pmc: PMC7387228
mid: NIHMS1590553
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1071-1078

Subventions

Organisme : NIAMS NIH HHS
ID : K24 AR048841
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000128
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002369
Pays : United States
Organisme : Medical Research Council
ID : MR/S021280/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U01 AG042124
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042145
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042168
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042140
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR052013
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG027810
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042139
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR066160
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR052000
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R56 AG061085
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042143
Pays : United States

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Auteurs

B G Faber (BG)

Medical Research Council Clinical Research Fellow, Musculoskeletal Research Unit, University of Bristol, Bristol, UK. Electronic address: ben.faber@bristol.ac.uk.

T L Bredbenner (TL)

Mechanical and Aerospace Engineering, University of Colorado Colorado Springs, Colorado, USA.

D Baird (D)

Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

J Gregory (J)

Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.

F Saunders (F)

Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.

C V Giuraniuc (CV)

Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.

R M Aspden (RM)

Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.

N E Lane (NE)

Center for Musculoskeletal Health, U.C. Davis School of Medicine, Sacramento, CA 95817, USA.

E Orwoll (E)

Bone and Mineral Unit, Oregon Health and Sciences University, Portland, OR, USA.

J H Tobias (JH)

Musculoskeletal Research Unit, University of Bristol, Bristol, UK.

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