Loss of m

Base Sequence / genetics Humans Neoplasms / genetics Nucleic Acid Conformation Oncogenes / genetics Pseudouridine / genetics RNA, Ribosomal / metabolism Ribosomal Proteins / metabolism Ribosomes / metabolism
RNA modification cancer colorectal carcinoma diffuse large B-cell lymphoma onco-ribosome rRNA variation ribosomal RNA ribosomal heterogeneity ribosome

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
05 05 2020
Historique:
received: 07 11 2019
revised: 03 02 2020
accepted: 14 04 2020
entrez: 7 5 2020
pubmed: 7 5 2020
medline: 4 6 2021
Statut: ppublish

Résumé

The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA). While mutations in ribosomal protein (RP) genes are known drivers of oncogenesis, oncogenic rRNA variants have remained elusive. We identify a cancer-specific single-nucleotide variation in 18S rRNA at nucleotide 1248.U in up to 45.9% of patients with colorectal carcinoma (CRC) and present across >22 cancer types. This is the site of a unique hyper-modified base, 1-methyl-3-α-amino-α-carboxyl-propyl pseudouridine (m

Identifiants

DOI: 10.1016/j.celrep.2020.107611 PMID: 32375039
pubmed: 32375039
pii: S2211-1247(20)30560-X
doi: 10.1016/j.celrep.2020.107611
pii:
doi:

Substances chimiques

RNA, Ribosomal 0
Ribosomal Proteins 0
Pseudouridine 1445-07-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

107611

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Artem Babaian (A)

Department of Medical Genetics, University of British Columbia, Vancouver, V6H 3N1 BC, Canada; Terry Fox Laboratory, BC Cancer, Vancouver, V5Z 1L3 BC, Canada. Electronic address: ababaian@bccrc.ca.

Katharina Rothe (K)

Department of Medical Genetics, University of British Columbia, Vancouver, V6H 3N1 BC, Canada; Terry Fox Laboratory, BC Cancer, Vancouver, V5Z 1L3 BC, Canada.

Dylan Girodat (D)

Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, T1K 3M4 AB, Canada.

Igor Minia (I)

Max Delbrück Center for Molecular Medicine Berlin in the Helmholtz Association, Berlin Institute for Medical Systems Biology, Berlin 13125, Germany.

Sara Djondovic (S)

Department of Medical Genetics, University of British Columbia, Vancouver, V6H 3N1 BC, Canada.

Miha Milek (M)

Max Delbrück Center for Molecular Medicine Berlin in the Helmholtz Association, Berlin Institute for Medical Systems Biology, Berlin 13125, Germany.

Sandra E Spencer Miko (SE)

Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, V6H 3N1 BC, Canada.

Hans-Joachim Wieden (HJ)

Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, T1K 3M4 AB, Canada.

Markus Landthaler (M)

Max Delbrück Center for Molecular Medicine Berlin in the Helmholtz Association, Berlin Institute for Medical Systems Biology, Berlin 13125, Germany; IRI Life Sciences, Institut für Biologie, Humboldt Universität, Berlin 10115, Germany.

Gregg B Morin (GB)

Department of Medical Genetics, University of British Columbia, Vancouver, V6H 3N1 BC, Canada; Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, V6H 3N1 BC, Canada.

Dixie L Mager (DL)

Department of Medical Genetics, University of British Columbia, Vancouver, V6H 3N1 BC, Canada; Terry Fox Laboratory, BC Cancer, Vancouver, V5Z 1L3 BC, Canada.

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Classifications MeSH

Recherchemedicale.com › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Loss of m
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss of m
Recherchemedicale.com › Tumeurs › Loss of m
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Loss of m
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Loss of m
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › Pseudouridine › Loss of m
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › Loss of m
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines ribosomiques › Loss of m
Recherchemedicale.com › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Ribosomes › Loss of m