Tryptophan catabolism reflects disease activity in human tuberculosis.

Adult Biomarkers / metabolism Female Gene Expression Regulation, Enzymologic Humans Indoleamine-Pyrrole 2,3,-Dioxygenase / biosynthesis Latent Tuberculosis / metabolism Male Mycobacterium tuberculosis / metabolism Tryptophan / metabolism Tuberculosis, Pulmonary / metabolism
Infectious disease Metabolism Tuberculosis

Journal

JCI insight
ISSN: 2379-3708
Titre abrégé: JCI Insight
Pays: United States
ID NLM: 101676073

Informations de publication

Date de publication:
21 05 2020
Historique:
received: 12 02 2020
accepted: 22 04 2020
pubmed: 6 5 2020
medline: 19 5 2021
entrez: 6 5 2020
Statut: epublish

Résumé

There is limited understanding of the role of host metabolism in the pathophysiology of human tuberculosis (TB). Using high-resolution metabolomics with an unbiased approach to metabolic pathway analysis, we discovered that the tryptophan pathway is highly regulated throughout the spectrum of TB infection and disease. This regulation is characterized by increased catabolism of tryptophan to kynurenine, which was evident not only in active TB disease but also in latent TB infection (LTBI). Further, we found that tryptophan catabolism is reversed with effective treatment of both active TB disease and LTBI in a manner commensurate with bacterial clearance. Persons with active TB and LTBI also exhibited increased expression of indoleamine 2,3-dioxygenase-1 (IDO-1), suggesting IDO-1 mediates observed increases in tryptophan catabolism. Together, these data indicate IDO-1-mediated tryptophan catabolism is highly preserved in the human response to Mycobacterium tuberculosis and could be a target for biomarker development as well as host-directed therapies.

Identifiants

DOI: 10.1172/jci.insight.137131 PMID: 32369456 PMC: PMC7259525
pubmed: 32369456
pii: 137131
doi: 10.1172/jci.insight.137131
pmc: PMC7259525
doi:
pii:

Substances chimiques

Biomarkers 0
IDO1 protein, human 0
Indoleamine-Pyrrole 2,3,-Dioxygenase 0
Tryptophan 8DUH1N11BX

Types de publication

Clinical Trial Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI144040
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111211
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002381
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW007124
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002378
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI087465
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI114444
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI130918
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI074492
Pays : United States

Références

Microbiol Mol Biol Rev. 2014 Sep;78(3):343-71
pubmed: 25184558
PLoS Med. 2013 Oct;10(10):e1001538
pubmed: 24167453
Cell. 2017 May 18;169(5):862-877.e17
pubmed: 28502771
PLoS One. 2012;7(5):e37314
pubmed: 22649518
J Expo Sci Environ Epidemiol. 2019 Jun;29(4):469-483
pubmed: 30518795
Clin Microbiol Rev. 2011 Jul;24(3):557-91
pubmed: 21734248
PLoS One. 2016 Oct 5;11(10):e0162220
pubmed: 27706152
Cell Host Microbe. 2018 Jul 11;24(1):34-42
pubmed: 30001523
Nat Commun. 2018 Dec 6;9(1):5208
pubmed: 30523338
J Am Heart Assoc. 2016 Oct 11;5(10):
pubmed: 27729334
Clin Infect Dis. 2017 Oct 15;65(8):1356-1358
pubmed: 29017244
BMC Bioinformatics. 2013 Jan 16;14:15
pubmed: 23323971
Cell. 2019 Sep 5;178(6):1313-1328.e13
pubmed: 31491384
Immunol Invest. 2012;41(6-7):765-97
pubmed: 23017145
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Immunity. 2005 May;22(5):633-42
pubmed: 15894280
PLoS Pathog. 2019 Aug 28;15(8):e1007955
pubmed: 31461509
Int J Tuberc Lung Dis. 2013 Nov;17(11):1501-6
pubmed: 24125458
Sci Transl Med. 2010 May 19;2(32):32ra36
pubmed: 20484731
Immunity. 2009 Dec 18;31(6):974-85
pubmed: 20064452
Clin Infect Dis. 2018 Apr 3;66(8):1246-1253
pubmed: 29293906
Nature. 2010 Aug 19;466(7309):973-7
pubmed: 20725040
Infect Drug Resist. 2019 May 14;12:1265-1276
pubmed: 31190914
PLoS One. 2015 Nov 18;10(11):e0142916
pubmed: 26581102
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
J Occup Environ Med. 2016 Aug;58(8 Suppl 1):S80-8
pubmed: 27501108
Cell. 2013 Dec 5;155(6):1296-308
pubmed: 24315099
Nat Immunol. 2001 Jan;2(1):64-8
pubmed: 11135580
Int J Tuberc Lung Dis. 2009 Jan;13(1):68-73
pubmed: 19105881
PLoS Pathog. 2012 Feb;8(2):e1002464
pubmed: 22363214
Infect Immun. 2001 Oct;69(10):6527-31
pubmed: 11553600
Clin Infect Dis. 2019 Apr 8;68(8):1274-1281
pubmed: 30107503
Comp Biochem Physiol B. 1973 Oct 15;46(2):273-6
pubmed: 4202192
J Infect Dis. 2013 Apr;207(7):1115-27
pubmed: 23255564
N Engl J Med. 2014 May 01;370(18):1712-1723
pubmed: 24785206
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E964-E973
pubmed: 29339504
Bioinformatics. 2010 Oct 1;26(19):2363-7
pubmed: 20688976
MMWR Recomm Rep. 2010 Jun 25;59(RR-5):1-25
pubmed: 20577159
Bioinformatics. 2009 Aug 1;25(15):1930-6
pubmed: 19414529
Metabolomics. 2013 Mar;9(1 Suppl):S132-S143
pubmed: 26229523
Eur J Cancer. 2017 May;76:167-182
pubmed: 28324751
Am J Respir Crit Care Med. 2012 Apr 1;185(7):779-84
pubmed: 22161161
PLoS Comput Biol. 2013;9(7):e1003123
pubmed: 23861661
Sci Rep. 2019 Dec 10;9(1):18669
pubmed: 31822686
PLoS One. 2013 Aug 05;8(8):e70630
pubmed: 23940611
Front Cell Infect Microbiol. 2018 Feb 06;8:13
pubmed: 29468141
BMC Genomics. 2013 Feb 01;14:74
pubmed: 23375113
Ann Am Thorac Soc. 2016 Jan;13(1):141-2
pubmed: 26730872
Clin Infect Dis. 2007 Jul 15;45(2):241-9
pubmed: 17578786
J Clin Microbiol. 2016 Feb;54(2):274-82
pubmed: 26582831
PLoS Med. 2015 Dec 29;12(12):e1001932
pubmed: 26714320
Nat Rev Drug Discov. 2019 May;18(5):379-401
pubmed: 30760888
Toxicol Rep. 2016;3:29-45
pubmed: 26722641
Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71
pubmed: 29255022
Science. 1998 Aug 21;281(5380):1191-3
pubmed: 9712583
MMWR Morb Mortal Wkly Rep. 2011 Dec 9;60(48):1650-3
pubmed: 22157884
Clin Vaccine Immunol. 2012 Mar;19(3):436-42
pubmed: 22219312
Bioinformatics. 2008 Jul 1;24(13):1547-8
pubmed: 18467348
Am J Clin Nutr. 2015 Nov;102(5):1059-69
pubmed: 26399865
Toxicol Sci. 2015 Dec;148(2):531-43
pubmed: 26358001
Am J Respir Crit Care Med. 2005 Nov 1;172(9):1169-227
pubmed: 16249321
Nat Rev Dis Primers. 2016 Oct 27;2:16076
pubmed: 27784885
Nucleic Acids Res. 2018 Jan 4;46(D1):D246-D251
pubmed: 29165655
Lancet Infect Dis. 2018 May;18(5):526-535
pubmed: 29395996

Auteurs

Jeffrey M Collins (JM)

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Amnah Siddiqa (A)

Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.

Dean P Jones (DP)

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Ken Liu (K)

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Russell R Kempker (RR)

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Azhar Nizam (A)

Department of Biostatistics and Bioinformatics.

N Sarita Shah (NS)

Department of Epidemiology, and.
Hubert Department of Global Health, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.

Nazir Ismail (N)

Centre for Tuberculosis, National Institute for Communicable Diseases, National Health Laboratory Services, Johannesburg, South Africa.
Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.
Department of Internal Medicine, University of Witwatersrand, Johannesburg, South Africa.

Samuel G Ouma (SG)

Kenya Medical Research Institute, Kisumu, Kenya.

Nestani Tukvadze (N)

National Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.

Shuzhao Li (S)

Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.

Cheryl L Day (CL)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory Vaccine Center and.
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Jyothi Rengarajan (J)

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory Vaccine Center and.
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

James Cm Brust (JC)

Division of General Internal Medicine and.
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.

Neel R Gandhi (NR)

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Department of Epidemiology, and.
Hubert Department of Global Health, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.

Joel D Ernst (JD)

Division of Experimental Medicine, Department of Medicine, UCSF School of Medicine, San Francisco, California, USA.

Henry M Blumberg (HM)

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Department of Epidemiology, and.
Hubert Department of Global Health, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Emory Vaccine Center and.

Thomas R Ziegler (TR)

Division of Endocrinology, Metabolism, and Lipids and.
Emory Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Section of Endocrinology, Atlanta Veterans Affairs Medical Center, Atlanta Georgia, USA.

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Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Tryptophan catabolism reflects disease...
Recherchemedicale.com › Facteurs biologiques › Marqueurs biologiques › Tryptophan catabolism reflects disease...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes codant pour des enzymes › Tryptophan catabolism reflects disease...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tryptophan catabolism reflects disease...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Indoleamine-pyrrole 2,3,-dioxygenase › Tryptophan catabolism reflects disease...
Recherchemedicale.com › Infection › Infection latente › Tuberculose latente › Tryptophan catabolism reflects disease...
Recherchemedicale.com › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Tryptophan catabolism reflects disease...
Recherchemedicale.com › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Tryptophan catabolism reflects disease...
Recherchemedicale.com › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Tuberculose pulmonaire › Tryptophan catabolism reflects disease...