Amphiphilic Star Polypept(o)ides as Nanomeric Vectors in Mucosal Drug Delivery.

Animals Drug Delivery Systems Peptides Pharmaceutical Preparations Polymers Rats Sarcosine

Journal

Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849

Informations de publication

Date de publication:
08 06 2020
Historique:
pubmed: 29 4 2020
medline: 22 6 2021
entrez: 29 4 2020
Statut: ppublish

Résumé

Mucosal delivery across the gastrointestinal (GI) tract, airways, and buccal epithelia is an attractive mode of therapeutic administration, but the challenge is to overcome the mucus and epithelial barriers. Here, we present degradable star polypept(o)ides capable of permeating both barriers as a promising biomaterial platform for mucosal delivery. Star polypept(o)ides were obtained by the initiation of benzyl-l-glutamate

Identifiants

DOI: 10.1021/acs.biomac.0c00381 PMID: 32343127
pubmed: 32343127
doi: 10.1021/acs.biomac.0c00381
doi:

Substances chimiques

Peptides 0
Pharmaceutical Preparations 0
Polymers 0
Sarcosine Z711V88R5F

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2455-2462

Auteurs

Dimitrios Skoulas (D)

Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin D02, Ireland.
Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CURAM), RCSI, Dublin 02 and University College Dublin,Dublin D04, Ireland.

Vivien Stuettgen (V)

School of Veterinary Medicine and Conway Institute, University College Dublin, Veterinary Science Centre, Belfield, Dublin D04, Ireland.
Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CURAM), RCSI, Dublin 02 and University College Dublin,Dublin D04, Ireland.

Rachel Gaul (R)

School of Pharmacy and Biomolecular Sciences and Tissue Engineering Research Group, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin D02, Ireland.

Sally-Ann Cryan (SA)

School of Pharmacy and Biomolecular Sciences and Tissue Engineering Research Group, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin D02, Ireland.
Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CURAM), RCSI, Dublin 02 and University College Dublin,Dublin D04, Ireland.
AMBER, The SFI Advanced Materials and Bioengineering Research Centre, RCSI, Dublin D02, Ireland.
ORCID: 0000-0002-3941-496X

David J Brayden (DJ)

School of Veterinary Medicine and Conway Institute, University College Dublin, Veterinary Science Centre, Belfield, Dublin D04, Ireland.
Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CURAM), RCSI, Dublin 02 and University College Dublin,Dublin D04, Ireland.
ORCID: 0000-0002-8781-8344

Andreas Heise (A)

Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin D02, Ireland.
Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CURAM), RCSI, Dublin 02 and University College Dublin,Dublin D04, Ireland.
AMBER, The SFI Advanced Materials and Bioengineering Research Centre, RCSI, Dublin D02, Ireland.
ORCID: 0000-0001-5916-8500

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Amphiphilic Star Polypept(o)ides as Nanomeric...
Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Amphiphilic Star Polypept(o)ides as Nanomeric...
Recherchemedicale.com › Acides aminés, peptides et protéines › Peptides › Amphiphilic Star Polypept(o)ides as Nanomeric...
Recherchemedicale.com › Préparations pharmaceutiques › Amphiphilic Star Polypept(o)ides as Nanomeric...
Recherchemedicale.com › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Amphiphilic Star Polypept(o)ides as Nanomeric...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Amphiphilic Star Polypept(o)ides as Nanomeric...
Recherchemedicale.com › Acides aminés, peptides et protéines › Acides aminés › Glycine › Sarcosine › Amphiphilic Star Polypept(o)ides as Nanomeric...