Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments in Mice.
Alzheimer's disease
beta-amyloid
cognitive impairment
protein methylation
protein phosphatase 2A
synaptic plasticity
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
03 06 2020
03 06 2020
Historique:
received:
12
12
2019
revised:
27
03
2020
accepted:
17
04
2020
pubmed:
29
4
2020
medline:
23
10
2020
entrez:
29
4
2020
Statut:
ppublish
Résumé
Beta-amyloid (Aβ) is thought to play a critical role in Alzheimer's disease (AD), and application of soluble oligomeric forms of Aβ produces AD-like impairments in cognition and synaptic plasticity in experimental systems. We found previously that transgenic overexpression of the PP2A methylesterase, PME-1, or the PP2A methyltransferase, LCMT-1, altered the sensitivity of mice to Aβ-induced impairments, suggesting that PME-1 inhibition may be an effective approach for preventing or treating these impairments. To explore this possibility, we examined the behavioral and electrophysiological effects of acutely applied synthetic Aβ oligomers in male and female mice heterozygous for either a
Identifiants
pubmed: 32341098
pii: JNEUROSCI.2983-19.2020
doi: 10.1523/JNEUROSCI.2983-19.2020
pmc: PMC7275859
doi:
Substances chimiques
Amyloid beta-Peptides
0
Lcmt1 protein, mouse
EC 2.1.1.-
Protein O-Methyltransferase
EC 2.1.1.-
Carboxylic Ester Hydrolases
EC 3.1.1.-
protein phosphatase methylesterase-1
EC 3.1.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4596-4608Subventions
Organisme : NINDS NIH HHS
ID : R01 NS092045
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS101134
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
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