Pharmacokinetic study of oral amitriptyline in horses.
analgesia
antidepressive agents
chronic pain
pharmacology
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
29
11
2019
revised:
13
03
2020
accepted:
05
04
2020
pubmed:
28
4
2020
medline:
30
4
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
The purpose of this study was to evaluate the pharmacokinetics of oral amitriptyline in horses. Oral amitriptyline (1 mg/kg) was administered to six horses. Blood samples were collected from jugular and lateral thoracic vein at predetermined times from 0 to 24 hr after administration. Plasma concentrations were determined by high-performance liquid chromatography and analyzed using noncompartmental methods. Pharmacodynamic parameters including heart rate, respiration rate, and intestinal motility were evaluated, and electrocardiographic examinations were performed in all subjects. The mean maximum plasma concentration (C
Substances chimiques
Antidepressive Agents, Tricyclic
0
Amitriptyline
1806D8D52K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
381-384Subventions
Organisme : Comisión Sectorial de Investigación Científica
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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