Hippocampal synaptic dysfunction in the SOD1
Adenosine A2 Receptor Antagonists
/ therapeutic use
Amyotrophic Lateral Sclerosis
/ genetics
Animals
Excitatory Postsynaptic Potentials
/ drug effects
Hippocampus
/ drug effects
Humans
Long-Term Potentiation
/ drug effects
Mice
Mice, Transgenic
Neuronal Plasticity
/ drug effects
Purines
/ therapeutic use
Receptor, Adenosine A2A
/ drug effects
Receptors, N-Methyl-D-Aspartate
/ drug effects
Superoxide Dismutase-1
/ genetics
Synapses
/ drug effects
Synaptic Transmission
/ drug effects
A(2A) receptor
ALS
Hippocampus
KW-6002
Long-term potentiation (LTP)
NMDA receptor
Neuronal plasticity
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
01
10
2019
revised:
08
04
2020
accepted:
09
04
2020
pubmed:
21
4
2020
medline:
29
6
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
Amyotrophic Lateral Sclerosis (ALS) mostly affects motor neurons, but non-motor neural and cognitive alterations have been reported in ALS mouse models and patients. Here, we evaluated if time-dependent biphasic changes in synaptic transmission and plasticity occur in hippocampal synapses of ALS SOD1
Identifiants
pubmed: 32311420
pii: S0028-3908(20)30174-X
doi: 10.1016/j.neuropharm.2020.108106
pii:
doi:
Substances chimiques
Adenosine A2 Receptor Antagonists
0
Purines
0
Receptor, Adenosine A2A
0
Receptors, N-Methyl-D-Aspartate
0
SOD1 protein, human
0
istradefylline
2GZ0LIK7T4
Superoxide Dismutase-1
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108106Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no competing interests.