Effect of continuous compressive force on the expression of RANKL, OPG, and VEGF in osteocytes.
Animals
Cell Line
Compressive Strength
Gadolinium
/ pharmacology
Gene Expression Regulation
Mice
Neovascularization, Physiologic
Osteoclasts
/ metabolism
Osteocytes
/ metabolism
Osteoprotegerin
/ biosynthesis
RANK Ligand
/ biosynthesis
Rats
Rats, Wistar
Tooth Movement Techniques
Vascular Endothelial Growth Factor A
/ biosynthesis
Journal
Biomedical research (Tokyo, Japan)
ISSN: 1880-313X
Titre abrégé: Biomed Res
Pays: Japan
ID NLM: 8100317
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
21
4
2020
pubmed:
21
4
2020
medline:
5
1
2021
Statut:
ppublish
Résumé
The present study aimed to investigate the effect of a compressive force (CF) on the expression of receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and vascular endothelial growth factor (VEGF) in murine osteocytes (MLO-Y4) as well as animal study. After application of a CF for 1, 3, 6, and 12 h, gene and protein expression of RANKL, OPG, and VEGF in MLO-Y4 cells were determined by real-time PCR and enzyme-linked immunosorbent assay (ELISA). Furthermore, the effect of a stretch-activated (S-A) channel was examined by gadolinium (Gd
Identifiants
pubmed: 32307402
doi: 10.2220/biomedres.41.91
doi:
Substances chimiques
Osteoprotegerin
0
RANK Ligand
0
Tnfrsf11b protein, mouse
0
Tnfrsf11b protein, rat
0
Tnfsf11 protein, mouse
0
Vascular Endothelial Growth Factor A
0
vascular endothelial growth factor A, mouse
0
vascular endothelial growth factor A, rat
0
Gadolinium
AU0V1LM3JT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM