Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia.
KAP1
TRIM28
fertility
haploinsufficiency
infertility
spermatogenesis
spermatogonial stem cells
Journal
Stem cell reports
ISSN: 2213-6711
Titre abrégé: Stem Cell Reports
Pays: United States
ID NLM: 101611300
Informations de publication
Date de publication:
12 05 2020
12 05 2020
Historique:
received:
08
01
2020
revised:
13
03
2020
accepted:
17
03
2020
pubmed:
18
4
2020
medline:
17
4
2021
entrez:
18
4
2020
Statut:
ppublish
Résumé
Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of particular interest. Here, we show that mice heterozygous for Trim28, an essential epigenetic regulator, suffer gradual testicular degeneration. Contrary to previous reports we detect Trim28 expression in spermatogonia, albeit at low levels. Further reduction through Trim28 heterozygosity increases the propensity of SSCs to differentiate at the cost of self-renewal.
Identifiants
pubmed: 32302554
pii: S2213-6711(20)30103-X
doi: 10.1016/j.stemcr.2020.03.013
pmc: PMC7220855
pii:
doi:
Substances chimiques
Trim28 protein, mouse
EC 2.3.2.27
Tripartite Motif-Containing Protein 28
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
818-827Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Genome Biol. 2010;11(11):R111
pubmed: 21092094
Science. 2010 Apr 2;328(5974):62-7
pubmed: 20299552
Development. 2017 Feb 15;144(4):624-634
pubmed: 28087628
Development. 2002 May;129(10):2329-37
pubmed: 11973266
Development. 2006 Apr;133(8):1495-505
pubmed: 16540512
Genes Dev. 2017 Jan 1;31(1):12-17
pubmed: 28115466
Nat Genet. 2002 Apr;30(4):365-6
pubmed: 11896389
Dev Biol. 2008 Sep 1;321(1):197-204
pubmed: 18601916
Biol Reprod. 1980 Jun;22(5):1233-43
pubmed: 7417656
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14976-80
pubmed: 18799751
Development. 2017 Sep 1;144(17):3022-3030
pubmed: 28851723
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Asian J Androl. 2010 Mar;12(2):263-70
pubmed: 20010847
Eur J Hum Genet. 2008 Nov;16(11):1350-7
pubmed: 18523451
Gene Expr. 2007;13(6):299-310
pubmed: 17708416
Reproduction. 2017 Aug;154(2):R55-R64
pubmed: 28624768
Genesis. 2008 Dec;46(12):738-42
pubmed: 18850594
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Genes Dev. 2015 Nov 1;29(21):2312-24
pubmed: 26545815
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12946-51
pubmed: 15328412
Science. 2012 Mar 23;335(6075):1499-502
pubmed: 22442485
Cell. 2016 Jan 28;164(3):353-64
pubmed: 26824653
Genes Dev. 2015 Mar 1;29(5):538-54
pubmed: 25737282
Development. 2004 Jan;131(2):459-67
pubmed: 14701682
PLoS One. 2018 Dec 20;13(12):e0208835
pubmed: 30571760
Stem Cell Reports. 2017 Dec 12;9(6):2065-2080
pubmed: 29198826
Science. 2013 Sep 6;341(6150):1110-2
pubmed: 24009393
Reproduction. 2008 Aug;136(2):131-46
pubmed: 18515312
Dis Model Mech. 2009 Jul-Aug;2(7-8):412-8
pubmed: 19535498
Genesis. 2007 Jun;45(6):413-7
pubmed: 17551945
Genetics. 2005 Apr;169(4):1915-25
pubmed: 15716499
Nature. 2010 Jan 14;463(7278):237-40
pubmed: 20075919
Curr Top Dev Biol. 2018;128:203-235
pubmed: 29477164
Development. 2000 Jul;127(13):2955-63
pubmed: 10851139
Cancer Res. 2006 Dec 15;66(24):11594-9
pubmed: 17178852
J Androl. 2008 May-Jun;29(3):251-9
pubmed: 18222914
Nat Commun. 2019 Jun 26;10(1):2787
pubmed: 31243281
Cold Spring Harb Protoc. 2017 Apr 3;2017(4):pdb.prot094185
pubmed: 28373492