Functionalized Lipopeptide Micelles as Highly Efficient NMR Depolarization Seed Points for Targeted Cell Labelling in Xenon MRI.
Xe Hyper-CEST
blood-brain barrier
lipopeptides
magnetic resonance imaging
nanocarriers
targeting
Journal
Advanced biosystems
ISSN: 2366-7478
Titre abrégé: Adv Biosyst
Pays: Germany
ID NLM: 101711718
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
22
10
2019
revised:
28
11
2019
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
7
9
2021
Statut:
ppublish
Résumé
Improving diagnostic imaging and therapy by targeted compound delivery to pathological areas and across biological barriers is of urgent need. A lipopeptide, P-CrA-A2, composed of a highly cationic peptide sequence (A2), an N-terminally attached palmitoyl chain (P) and cryptophane molecule (CrA) for preferred uptake into blood-brain barrier (BBB) capillary endothelial cells, was generated. CrA allows reversible binding of Xe for NMR detection with hyperpolarized nuclei. The lipopeptide forms size-optimized micelles with a diameter of about 11 nm at low micromolar concentration. Their high local CrA payload has a strong and switchable impact on the bulk magnetization through Hyper-CEST detection. Covalent fixation of CrA does not impede micelle formation and does not hamper its host functionality but simplifies Xe access to hosts for inducing saturation transfer. Xe Hyper-CEST magnetic resonance imaging (MRI) allows for distinguishing BBB endothelial cells from control aortic endothelial cells, and the small micelle volume with a sevenfold improved CrA-loading density compared to liposomal carriers allows preferred cell labelling with a minimally invasive volume (≈16 000-fold more efficient than
Identifiants
pubmed: 32293139
doi: 10.1002/adbi.201900251
doi:
Substances chimiques
Fluorescent Dyes
0
Lipopeptides
0
Micelles
0
Xenon
3H3U766W84
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e1900251Informations de copyright
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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