Association of liver biomarkers and cytokeratin-18 in Nonalcoholic fatty liver disease patients.
Cytokeration18
Liver biomarkers
Non-Alcoholic fatty liver disease
Journal
Pakistan journal of medical sciences
ISSN: 1682-024X
Titre abrégé: Pak J Med Sci
Pays: Pakistan
ID NLM: 100913117
Informations de publication
Date de publication:
Historique:
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
ppublish
Résumé
To investigate the association of gold standard liver biomarkers with serum cytokeratin 18 (CK18), serum Alanine aminotransferase (ALT) and serum aspartate (AST). This was cross sectional study. It was conducted at Mayo Hospital from January 2016 to December 2017. It comprised of 148 non-alcoholic fatty liver disease subjects of age 40-60 years. After written informed consent, study anthropometric measurements (age, height, waist circumference and hip circumference) were taken and serum AST, ALT and CK-18 were estimated by sandwiched ELISA technique. Data was analyzed using SPSS 21.0. Descriptive were presented as mean and standard deviation. Association between CK18, serum AST and ALT were analyzed by regression analysis and are presented as beta coefficient. P-value ≤ 0.05 was taken as significant. Study comprised of 148 subjects with mean age 44.81±6.2. Of total population 29.1% were male and 70.9% were female. Significant positive association of CK18 was found with serum ALT (P-value 0.005*). However, no association was found between AST and serum CK18. (P-value 0.29). Significant positive association was found between Serum CK18 and serum ALT.
Identifiants
pubmed: 32292439
doi: 10.12669/pjms.36.3.1674
pii: PJMS-39-387
pmc: PMC7150401
doi:
Types de publication
Journal Article
Langues
eng
Pagination
387-390Informations de copyright
Copyright: © Pakistan Journal of Medical Sciences.
Déclaration de conflit d'intérêts
Conflict of interest: None.
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