Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.
adjuvant treatment
chemotherapy
monitoring
supplementation
trace element
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
12 Apr 2020
12 Apr 2020
Historique:
received:
18
03
2020
revised:
08
04
2020
accepted:
09
04
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
12
1
2021
Statut:
epublish
Résumé
Selenoprotein P (SELENOP) is an established biomarker of selenium (Se) status. Serum SELENOP becomes saturated with increasing Se intake, reaching maximal concentrations of 5-7 mg SELENOP/L at intakes of ca. 100-150 µg Se/d. A biomarker for higher Se intake is missing. We hypothesized that SELENOP may also reflect Se status in clinical applications of therapeutic dosages of selenite. To this end, blood samples from two supplementation studies employing intravenous application of selenite at dosages >1 mg/d were analyzed. Total Se was quantified by spectroscopy, and SELENOP by a validated ELISA. The high dosage selenite infusions increased SELENOP in parallel to elevated Se concentrations relatively fast to final values partly exceeding 10 mg SELENOP/L. Age or sex were not related to the SELENOP increase. Western blot analyses of SELENOP verified the results obtained by ELISA, and indicated an unchanged pattern of immunoreactive protein isoforms. We conclude that the saturation of SELENOP concentrations observed in prior studies with moderate Se dosages (<400 µg/d) may reflect an intermediate plateau of expression, rather than an absolute upper limit. Circulating SELENOP seems to be a suitable biomarker for therapeutic applications of selenite exceeding the recommended upper intake levels. Whether SELENOP is also capable of reflecting other supplemental selenocompounds in high dosage therapeutic applications remains to be investigated.
Identifiants
pubmed: 32290626
pii: nu12041067
doi: 10.3390/nu12041067
pmc: PMC7230801
pii:
doi:
Substances chimiques
Biomarkers
0
Selenoprotein P
0
Selenium
H6241UJ22B
Types de publication
Clinical Trial, Phase I
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Cancerfonden
ID : xyz
Organisme : Radiumhemmets Forskningsfonder
ID : xyz
Organisme : Deutsche Forschungsgemeinschaft
ID : Scho 849/6-1
Références
Am J Clin Nutr. 2010 Sep;92(3):525-31
pubmed: 20573787
Metallomics. 2012 Jun;4(6):533-8
pubmed: 22552441
J Clin Endocrinol Metab. 2017 Nov 1;102(11):4333-4341
pubmed: 29092078
J Trace Elem Med Biol. 2019 Jan;51:141-149
pubmed: 30466924
Annu Rev Nutr. 2005;25:215-35
pubmed: 16011466
Crit Care Med. 2007 Jan;35(1):118-26
pubmed: 17095947
Hormones (Athens). 2020 Mar;19(1):15-24
pubmed: 31823341
Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2958-68
pubmed: 20852007
Crit Care. 2014 Apr 09;18(2):R68
pubmed: 24716537
Mol Nutr Food Res. 2008 Nov;52(11):1235-46
pubmed: 18686295
Breast Cancer Res Treat. 2018 Jan;167(2):591-598
pubmed: 29043463
J Clin Endocrinol Metab. 2015 Nov;100(11):4037-47
pubmed: 26305620
Adv Food Nutr Res. 2003;47:73-112
pubmed: 14639782
Nutrients. 2015 Mar 31;7(4):2209-36
pubmed: 25835046
PLoS One. 2012;7(10):e46644
pubmed: 23056383
J Nutr. 1996 Jan;126(1):138-45
pubmed: 8558294
Am J Physiol. 1991 Jul;261(1 Pt 1):E26-30
pubmed: 1858872
Am J Clin Nutr. 2010 Apr;91(4):923-31
pubmed: 20181815
Nat Genet. 2005 Nov;37(11):1247-52
pubmed: 16228000
Carcinogenesis. 2009 Sep;30(9):1553-61
pubmed: 19578042
Breast Cancer Res Treat. 2012 Aug;134(3):1269-77
pubmed: 22736377
Nutrition. 2013 Jan;29(1):158-65
pubmed: 23010420
Redox Biol. 2017 Apr;11:403-414
pubmed: 28064116
Sci Transl Med. 2018 Feb 14;10(428):
pubmed: 29444979
N Engl J Med. 2014 May 1;370(18):1756-60
pubmed: 24785212
Biochim Biophys Acta. 2009 Nov;1790(11):1453-62
pubmed: 19328222
Br J Nutr. 2016 Aug;116(3):504-13
pubmed: 27267586
Indian J Crit Care Med. 2017 May;21(5):287-293
pubmed: 28584432
Antioxid Redox Signal. 2013 Jul 10;19(2):181-91
pubmed: 23421468
Br J Nutr. 2012 May;107(10):1514-25
pubmed: 21936966
Physiol Rev. 2014 Jul;94(3):739-77
pubmed: 24987004
Am J Clin Nutr. 2016 Aug;104(2):406-14
pubmed: 27357089
Biol Trace Elem Res. 2016 Mar;170(1):25-32
pubmed: 26198135
Crit Care. 2007;11(4):R73
pubmed: 17617901
Nutrients. 2015 Jun 19;7(6):4978-94
pubmed: 26102212
Br J Nutr. 2010 Dec;104(11):1601-4
pubmed: 20637135
Int J Cancer. 2015 Mar 1;136(5):1149-61
pubmed: 25042282
Lancet. 2012 Mar 31;379(9822):1256-68
pubmed: 22381456
Nutrients. 2015 May 13;7(5):3536-56
pubmed: 25984742
Crit Care Med. 2011 Aug;39(8):1879-85
pubmed: 21460705
Nutrients. 2015 Apr 27;7(5):3094-118
pubmed: 25923656
Nutrients. 2013 Mar 05;5(3):700-10
pubmed: 23462585
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):804-10
pubmed: 16614127
Am J Clin Nutr. 1990 Dec;52(6):1087-93
pubmed: 2239787