Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use.

COVID-19 Coronavirus Infections / physiopathology Drug Development Mesenchymal Stem Cells / metabolism Metabolome Pandemics Pneumonia, Viral / physiopathology
COVID-19 SARS-CoV-2 acute respiratory distress syndrome exosomes extracellular vesicles mesenchymal stem cells microvesicles secretome

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
09 04 2020
Historique:
received: 21 03 2020
revised: 07 04 2020
accepted: 08 04 2020
entrez: 15 4 2020
pubmed: 15 4 2020
medline: 16 4 2020
Statut: epublish

Résumé

From the end of 2019, the world population has been faced the spread of the novel coronavirus SARS-CoV-2 responsible for COVID-19 infection. In approximately 14% of the patients affected by the novel coronavirus, the infection progresses with the development of pneumonia that requires mechanical ventilation. At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. In our opinion, mesenchymal stem cell secretome could offer a new therapeutic approach in treating COVID-19 pneumonia, due to the broad pharmacological effects it shows, including anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties.

Identifiants

DOI: 10.3390/cells9040924 PMID: 32283815 PMC: PMC7226831
pubmed: 32283815
pii: cells9040924
doi: 10.3390/cells9040924
pmc: PMC7226831
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Interreg V-A Italy-Switzerland 2014-2020
ID : Project ID 637541
Pays : International

Déclaration de conflit d'intérêts

M.L.T., S.P. and A.G.C. are co-founders and members of the advisory board of PharmaExceed S.r.l.

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Auteurs

Elia Bari (E)

Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.

Ilaria Ferrarotti (I)

.Center for Diagnosis of Inherited Alpha1-antitrypsin Deficiency, Department of Internal Medicine and Therapeutics, Pneumology Unit IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, Italy.

Laura Saracino (L)

Pneumology Unit IRCCS San Matteo Hospital Foundation, 27100 Pavia, Italy.

Sara Perteghella (S)

Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
PharmaExceed S.r.l., 27100 Pavia, Italy.

Maria Luisa Torre (ML)

Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
PharmaExceed S.r.l., 27100 Pavia, Italy.

Angelo Guido Corsico (AG)

.Center for Diagnosis of Inherited Alpha1-antitrypsin Deficiency, Department of Internal Medicine and Therapeutics, Pneumology Unit IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, Italy.
PharmaExceed S.r.l., 27100 Pavia, Italy.

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Classifications MeSH

Recherchemedicale.com › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Mesenchymal Stromal Cell Secretome for Severe...
Recherchemedicale.com › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › Mesenchymal Stromal Cell Secretome for Severe...
Recherchemedicale.com › Techniques d'investigation › Développement de médicament › Mesenchymal Stromal Cell Secretome for Severe...
Recherchemedicale.com › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Mesenchymal Stromal Cell Secretome for Severe...
Recherchemedicale.com › Métabolisme › Métabolome › Mesenchymal Stromal Cell Secretome for Severe...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › Mesenchymal Stromal Cell Secretome for Severe...
Recherchemedicale.com › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › Mesenchymal Stromal Cell Secretome for Severe...