Vaccines to prevent genital herpes.
Journal
Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
06
01
2020
revised:
02
03
2020
accepted:
09
03
2020
pubmed:
10
4
2020
medline:
26
9
2020
entrez:
10
4
2020
Statut:
ppublish
Résumé
Genital herpes increases the risk of acquiring and transmitting Human Immunodeficiency Virus (HIV), is a source of anxiety for many about transmitting infection to intimate partners, and is life-threatening to newborns. A vaccine that prevents genital herpes infection is a high public health priority. An ideal vaccine will prevent both genital lesions and asymptomatic subclinical infection to reduce the risk of inadvertent transmission to partners, will be effective against genital herpes caused by herpes simplex virus types 1 and 2 (HSV-1, HSV-2), and will protect against neonatal herpes. Three phase 3 human trials were performed over the past 20 years that used HSV-2 glycoproteins essential for virus entry as immunogens. None achieved its primary endpoint, although each was partially successful in either delaying onset of infection or protecting a subset of female subjects that were HSV-1 and HSV-2 uninfected against HSV-1 genital infection. The success of future vaccine candidates may depend on improving the predictive value of animal models by requiring vaccines to achieve near-perfect protection in these models and by using the models to better define immune correlates of protection. Many vaccine candidates are under development, including DNA, modified mRNA, protein subunit, killed virus, and attenuated live virus vaccines. Lessons learned from prior vaccine studies and select candidate vaccines are discussed, including a trivalent nucleoside-modified mRNA vaccine that our laboratory is pursuing. We are optimistic that an effective vaccine for prevention of genital herpes will emerge in this decade.
Identifiants
pubmed: 32272093
pii: S1931-5244(20)30041-4
doi: 10.1016/j.trsl.2020.03.004
pmc: PMC7293938
mid: NIHMS1584204
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Viral Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
138-152Subventions
Organisme : NIAID NIH HHS
ID : R01 AI139618
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI118684
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007180
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Methods Mol Biol. 2013;969:43-54
pubmed: 23296926
J Infect Dis. 1989 Jan;159(1):89-95
pubmed: 2535869
Cell. 2017 Jul 13;170(2):273-283.e12
pubmed: 28708997
J Infect Dis. 2009 Oct 1;200(7):1088-95
pubmed: 19702506
PLoS Pathog. 2018 May 23;14(5):e1007095
pubmed: 29791513
BMJ. 2008 Jan 5;336(7634):36-40
pubmed: 18174598
J Infect Dis. 2005 May 15;191(10):1734-46
pubmed: 15838802
J Med Primatol. 2017 Aug;46(4):121-128
pubmed: 28748667
PLoS One. 2015 Dec 15;10(12):e0145228
pubmed: 26670699
J Immunol. 2015 Jul 1;195(1):329-38
pubmed: 25994965
Vaccine. 2009 Feb 5;27(6):940-6
pubmed: 19071187
Vaccine. 2019 Oct 8;37(43):6470-6477
pubmed: 31515143
Mol Ther. 2008 Nov;16(11):1833-40
pubmed: 18797453
Mol Ther. 2015 Sep;23(9):1416-7
pubmed: 26321183
Lancet Infect Dis. 2020 Feb;20(2):240-249
pubmed: 31753763
J Virol. 2019 Jan 4;93(2):
pubmed: 30333177
Ann Intern Med. 1995 Jun 15;122(12):889-98
pubmed: 7755223
Vaccine. 2011 Aug 11;29(35):5824-36
pubmed: 21718746
Sex Transm Dis. 2003 Feb;30(2):174-7
pubmed: 12567178
J Infect Dis. 2019 Aug 9;220(6):990-1000
pubmed: 31058977
J Infect Dis. 2003 Feb 15;187(4):542-9
pubmed: 12599070
N Engl J Med. 1997 Aug 21;337(8):509-15
pubmed: 9262493
Vaccine. 2020 Feb 24;38(9):2250-2257
pubmed: 31767462
Cell Host Microbe. 2018 Aug 8;24(2):234-248.e5
pubmed: 30092200
Immunity. 2014 Oct 16;41(4):529-42
pubmed: 25367570
J Infect Dis. 1982 Sep;146(3):397-404
pubmed: 6286797
Mucosal Immunol. 2016 Nov;9(6):1571-1583
pubmed: 27007679
PLoS One. 2015 Jan 21;10(1):e114989
pubmed: 25608026
PLoS One. 2015 Oct 28;10(10):e0140765
pubmed: 26510007
J Virol. 1991 Dec;65(12):7046-50
pubmed: 1658396
Ann Intern Med. 1983 Jun;98(6):958-72
pubmed: 6344712
Cell. 2017 Mar 9;168(6):1114-1125.e10
pubmed: 28222903
J Immunol. 2010 Mar 15;184(6):3250-9
pubmed: 20164419
Virology. 2019 Jan 2;526:180-188
pubmed: 30412859
PLoS Med. 2017 Dec 27;14(12):e1002475
pubmed: 29281620
Nat Commun. 2018 Aug 22;9(1):3361
pubmed: 30135514
Actas Dermosifiliogr. 2020 Jan 2;111(1):53-58
pubmed: 31744595
JAMA. 2003 Jan 8;289(2):203-9
pubmed: 12517231
JCI Insight. 2016 Aug 4;1(12):
pubmed: 27536733
J Infect Dis. 2014 Aug 15;210(4):571-5
pubmed: 24652496
J Virol. 1992 Apr;66(4):2157-69
pubmed: 1312626
Vaccine. 2014 Mar 10;32(12):1398-406
pubmed: 24462481
N Engl J Med. 2011 Oct 6;365(14):1284-92
pubmed: 21991950
Sex Transm Dis. 2019 Dec;46(12):795-800
pubmed: 31764767
PLoS One. 2011 Mar 11;6(3):e17748
pubmed: 21412438
Mucosal Immunol. 2008 Nov;1(6):489-96
pubmed: 19079216
Vaccine. 2019 May 31;37(25):3326-3334
pubmed: 31079849
PLoS Pathog. 2017 Jun 14;13(6):e1006430
pubmed: 28614387
J Infect Dis. 2014 Mar;209(6):828-36
pubmed: 24285844
J Virol. 2003 Sep;77(18):9845-51
pubmed: 12941893
BMC Biol. 2010 Apr 12;8:37
pubmed: 20385031
Lancet. 2017 Sep 23;390(10101):1511-1520
pubmed: 28754494
J Infect Dis. 1987 Jan;155(1):28-37
pubmed: 3025306
J R Soc Interface. 2014 Mar 26;11(95):20140160
pubmed: 24671939
J Virol. 2012 Feb;86(4):2273-81
pubmed: 22171256
PLoS Pathog. 2017 Jan 19;13(1):e1006141
pubmed: 28103319
J Virol. 2014 Aug;88(15):8421-32
pubmed: 24829358
J Virol. 2011 Oct;85(20):10472-86
pubmed: 21813597
J Infect Dis. 2000 Jan;181(1):335-9
pubmed: 10608784
Viruses. 2012 May;4(5):800-32
pubmed: 22754650
Virology. 2018 Jan 1;513:129-135
pubmed: 29069622
J Control Release. 2015 Nov 10;217:345-51
pubmed: 26264835
Lancet Glob Health. 2017 Mar;5(3):e300-e309
pubmed: 28153513
N Engl J Med. 2000 Mar 23;342(12):844-50
pubmed: 10727588
Vaccine. 2019 Jun 27;37(29):3770-3778
pubmed: 31153687
Elife. 2015 Mar 10;4:
pubmed: 25756612
Semin Perinatol. 2018 Apr;42(3):168-175
pubmed: 29544668
Immunol Rev. 2017 Jan;275(1):49-61
pubmed: 28133798
NPJ Vaccines. 2019 Aug 1;4:33
pubmed: 31396405
N Engl J Med. 2012 Jan 5;366(1):34-43
pubmed: 22216840
Virol J. 2005 Aug 18;2:67
pubmed: 16109179
J Virol. 2014 Jul;88(14):7786-95
pubmed: 24789783
JAMA. 1999 Jul 28;282(4):331-40
pubmed: 10432030
J Neurovirol. 2015 Feb;21(1):8-23
pubmed: 25388226
J Virol. 1982 Jan;41(1):137-44
pubmed: 6283108
J Exp Med. 2018 Jun 4;215(6):1571-1588
pubmed: 29739835
PLoS One. 2015 Feb 06;10(2):e0116091
pubmed: 25658852
Vaccine. 2012 Oct 12;30(46):6541-6550
pubmed: 22947141
PLoS One. 2013 Oct 03;8(10):e76407
pubmed: 24098493
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15438-43
pubmed: 25316792
J Virol. 2005 Jan;79(1):410-8
pubmed: 15596834
Sci Immunol. 2019 Sep 20;4(39):
pubmed: 31541030
Nature. 2017 Mar 9;543(7644):248-251
pubmed: 28151488
PLoS One. 2009 Nov 30;4(11):e8060
pubmed: 20011586
Pediatrics. 2001 Aug;108(2):230-8
pubmed: 11483782
J Infect Dis. 2018 Feb 14;217(5):754-758
pubmed: 29216362
J Infect Dis. 2002 Jan 1;185(1):45-52
pubmed: 11756980
J Infect Dis. 2005 Dec 15;192(12):2117-23
pubmed: 16288376
Mol Ther. 2017 Jun 7;25(6):1316-1327
pubmed: 28457665
N Engl J Med. 1991 Feb 14;324(7):450-4
pubmed: 1988830
Immunity. 2010 Oct 29;33(4):492-503
pubmed: 21029960
Clin Infect Dis. 2013 Feb;56(3):344-51
pubmed: 23087395
J Infect Dis. 2020 Feb 18;221(5):729-738
pubmed: 31599942
Clin Microbiol Rev. 2004 Jan;17(1):1-13
pubmed: 14726453
J Virol. 2011 Apr;85(7):3239-49
pubmed: 21228231
N Engl J Med. 2002 Nov 21;347(21):1652-61
pubmed: 12444179
J Infect Dis. 1989 Nov;160(5):770-6
pubmed: 2553825
Vaccine. 2016 Jan 2;34(1):101-9
pubmed: 26571309
PLoS One. 2015 Apr 02;10(4):e0121518
pubmed: 25837802
J Reprod Immunol. 2008 Jun;78(1):58-67
pubmed: 17950908
Vaccine. 2019 Jan 3;37(1):61-68
pubmed: 30471955
N Engl J Med. 1987 Jan 29;316(5):240-4
pubmed: 3025727
PLoS One. 2012;7(10):e46714
pubmed: 23071620
AIDS. 2006 Jan 2;20(1):73-83
pubmed: 16327322
J Clin Microbiol. 1990 Jan;28(1):11-5
pubmed: 2153698
Sex Transm Dis. 2010 May;37(5):290-7
pubmed: 20351622
Virology. 2016 Jan 15;488:61-7
pubmed: 26609935
JAMA. 2016 Dec 20;316(23):2531-2543
pubmed: 27997660
J Virol. 2012 Feb;86(3):1563-76
pubmed: 22130533
J Infect Dis. 2019 Jul 31;220(5):852-861
pubmed: 31111902
Annu Rev Immunol. 2016 May 20;34:575-608
pubmed: 27168245
PLoS One. 2019 Mar 27;14(3):e0213401
pubmed: 30917165
J Virol. 2015 Nov 11;90(1):562-74
pubmed: 26559846
Nat Rev Immunol. 2015 Mar;15(3):185-9
pubmed: 25677493
J Virol. 2017 Apr 13;91(9):
pubmed: 28228587
Hum Vaccin Immunother. 2017 Dec 2;13(12):2785-2793
pubmed: 28481687
J Immunol. 2019 Nov 15;203(10):2655-2664
pubmed: 31578266
JAMA. 2000 Feb 9;283(6):746; author reply 746-7
pubmed: 10683051
JAMA. 2011 Apr 13;305(14):1441-9
pubmed: 21486977