Breakdown of the affective-cognitive network in functional dystonia.
Adult
Affect
/ physiology
Amygdala
/ diagnostic imaging
Brain
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Cognition
/ physiology
Connectome
Cross-Sectional Studies
Dystonic Disorders
/ diagnostic imaging
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Somatoform Disorders
/ diagnostic imaging
Young Adult
affective-cognitive network
brain functional connectivity
fMRI
functional dystonia
resting state fMRI
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
received:
11
09
2019
revised:
13
02
2020
accepted:
15
03
2020
pubmed:
4
4
2020
medline:
11
11
2021
entrez:
4
4
2020
Statut:
ppublish
Résumé
Previous studies suggested that brain regions subtending affective-cognitive processes can be implicated in the pathophysiology of functional dystonia (FD). In this study, the role of the affective-cognitive network was explored in two phenotypes of FD: fixed (FixFD) and mobile dystonia (MobFD). We hypothesized that each of these phenotypes would show peculiar functional connectivity (FC) alterations in line with their divergent disease clinical expressions. Resting state fMRI (RS-fMRI) was obtained in 40 FD patients (12 FixFD; 28 MobFD) and 43 controls (14 young FixFD-age-matched [yHC]; 29 old MobFD-age-matched [oHC]). FC of brain regions of interest, known to be involved in affective-cognitive processes, and independent component analysis of RS-fMRI data to explore brain networks were employed. Compared to HC, all FD patients showed reduced FC between the majority of affective-cognitive seeds of interest and the fronto-subcortical and limbic circuits; enhanced FC between the right affective-cognitive part of the cerebellum and the bilateral associative parietal cortex; enhanced FC of the bilateral amygdala with the subcortical and posterior cortical brain regions; and altered FC between the left medial dorsal nucleus and the sensorimotor and associative brain regions (enhanced in MobFD and reduced in FixFD). Compared with yHC and MobFD patients, FixFD patients had an extensive pattern of reduced FC within the cerebellar network, and between the majority of affective-cognitive seeds of interest and the sensorimotor and high-order function ("cognitive") areas with a unique involvement of dorsal anterior cingulate cortex connectivity. Brain FC within the affective-cognitive network is altered in FD and presented specific features associated with each FD phenotype, suggesting an interaction between brain connectivity and clinical expression of the disease.
Identifiants
pubmed: 32243055
doi: 10.1002/hbm.24997
pmc: PMC7336141
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3059-3076Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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