αB-crystallin response to a pro-oxidant non-cytotoxic environment in murine cardiac cells: An "in vitro" and "in vivo" study.
Cardiac muscle
Endurance exercise
HSPB5
Oxidative eustress
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
20 05 2020
20 05 2020
Historique:
received:
03
12
2019
revised:
11
03
2020
accepted:
20
03
2020
pubmed:
1
4
2020
medline:
22
6
2021
entrez:
1
4
2020
Statut:
ppublish
Résumé
The αB-crystallin (HSPB5) protein is modulated in response to a wide variety of stressors generated by multiple physio-pathological conditions, sustained by reactive oxygen species (ROS) production. In cardiac muscle tissue, this protein regulates various cellular processes, such as protein degradation, apoptosis and the stabilization of cytoskeletal elements. In this work, we studied the role of HSPB5 expression, activation and localization in HL-1 murine cardiomyocytes exposed to pro-oxidant and non-cytotoxic H
Identifiants
pubmed: 32224085
pii: S0891-5849(19)32445-1
doi: 10.1016/j.freeradbiomed.2020.03.013
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
alpha-Crystallin B Chain
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-312Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that there are not conflicts of interest.