Proteoglycan synthesis rate as a novel method to measure blood-induced cartilage degeneration in non-haemophilic and haemophilic rats.
arthropathies
cartilage
experimental animal models
haemarthrosis
haemophilia
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
ISSN: 1365-2516
Titre abrégé: Haemophilia
Pays: England
ID NLM: 9442916
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
09
10
2019
revised:
26
02
2020
accepted:
02
03
2020
pubmed:
27
3
2020
medline:
15
12
2020
entrez:
27
3
2020
Statut:
ppublish
Résumé
Haemophilic animal models are used to study blood-induced cartilage damage, but quantitative and sensitive outcome measures are needed. To develop a novel quantitative method for detecting early cartilage degeneration in a haemophilic rat model of blood-induced joint damage. The In vitro, a decrease in PSR in tibial and patellar cartilage was demonstrated following blood exposure. In vivo, joint diameter and development of bone pathology confirmed successful induction of haemarthrosis. In the blood-exposed knee, tibial and patellar PSR was inhibited 4 and 16 days after induced haemarthrosis. Interestingly, at day 16 the proteoglycan synthesis in the contralateral knee was also inhibited to an extent correlating with that of the blood-exposed knee. For the first time, early changes in cartilage matrix synthesis upon blood exposure were quantified with the
Identifiants
pubmed: 32212362
doi: 10.1111/hae.13969
pmc: PMC7318356
doi:
Substances chimiques
Proteoglycans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e88-e96Subventions
Organisme : Novo Nordisk A/S
Informations de copyright
© 2020 The Authors. Haemophilia published by John Wiley & Sons Ltd.
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