Fetal profile in fetuses with open spina bifida.
Frontomaxillary angle
Prefrontal space ratio
Profile
Spina bifida
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
27
11
2019
accepted:
09
03
2020
pubmed:
27
3
2020
medline:
15
9
2020
entrez:
27
3
2020
Statut:
ppublish
Résumé
To determine whether the frontomaxillary facial (FMF) angle and the prefrontal space ratio (PFSR) are helpful in screening for open spinal defects by ultrasound in the second and third trimesters of pregnancy. The FMF angle and the PFSR were measured in fetuses with spina bifida according to standardized protocols. The normal range of the PFSR was previously published by our group. To determine the normal values for the FMF angle in the second and third trimesters of pregnancy, we used the same stored images from the above-mentioned study. 71 affected and 279 normal fetuses were included in this study. Median gestational ages in the two groups were 21.1 weeks and 21.6 weeks, respectively. In fetuses with spina bifida, the FMF angle was significantly smaller than in the normal population (72.9° versus 79.6°). However, the measurement was below the fifth centile in only 22.5% of the affected fetuses. The PFSR was similar in both groups. The FMF angle is smaller in second and third trimester fetuses with open spina bifida. However, the difference is not large enough to implement this marker in current screening programs.
Identifiants
pubmed: 32211952
doi: 10.1007/s00404-020-05503-8
pii: 10.1007/s00404-020-05503-8
pmc: PMC7181420
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1167-1171Références
BJOG. 2008 May;115(6):689-96
pubmed: 18410651
Childs Nerv Syst. 2017 Jul;33(7):1083-1099
pubmed: 28593553
Prenat Diagn. 2015 Mar;35(3):228-35
pubmed: 25346419
Prenat Diagn. 2011 Jan;31(1):103-6
pubmed: 21188735
Ultrasound Obstet Gynecol. 2010 Sep;36(3):268-71
pubmed: 20549771
Ultrasound Obstet Gynecol. 2008 Jul;32(1):5-11
pubmed: 18512854
Ultrasound Obstet Gynecol. 2013 Mar;41(3):262-6
pubmed: 22791586
Ultraschall Med. 2017 Apr;38(2):151-157
pubmed: 25876171
Lancet. 1986 Jul 12;2(8498):72-4
pubmed: 2425202
Ultrasound Obstet Gynecol. 2012 Jun;39(6):636-41
pubmed: 21830246
Semin Fetal Neonatal Med. 2010 Feb;15(1):9-14
pubmed: 19540177
Childs Nerv Syst. 2017 Jul;33(7):1101-1106
pubmed: 28510070
Am J Obstet Gynecol. 2007 Aug;197(2):160.e1-5
pubmed: 17689634
Ultrasound Obstet Gynecol. 2012 Sep;40(3):293-6
pubmed: 22302766
Fetal Diagn Ther. 2020;47(2):115-122
pubmed: 31212296
BMJ. 2015 Nov 24;351:h5949
pubmed: 26601850
Fetal Diagn Ther. 2015;37(4):301-4
pubmed: 25614077
Ultrasound Obstet Gynecol. 2008 Apr;31(4):384-7
pubmed: 18318458