Clinical, serological, histopathological and treatment profile of autoimmune hepatitis in the elderly.
acute-on-chronic liver failure
autoimmune hepatitis (AIH)
treatment outcomes in autoimmune hepatitis
Journal
Clinical and experimental hepatology
ISSN: 2392-1099
Titre abrégé: Clin Exp Hepatol
Pays: Poland
ID NLM: 101703431
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
15
07
2019
accepted:
16
10
2019
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
14
3
2020
Statut:
ppublish
Résumé
Autoimmune hepatitis (AIH), despite being uncommon, is on the rise in the elderly population. However, no study from India has described the natural history and treatment outcome of AIH in the elderly. The aim was to study the characteristics of AIH in the elderly population and compare them with the younger population. Patients with a diagnosis of AIH based on the revised International Autoimmune Hepatitis Group (IAIHG) criteria were recruited from January 2011 to June 2018. Patients were defined as elderly when ≥ 60 years and young when < 60 years of age. Clinical, serological, histological characteristics and treatment outcome with follow-up until 12 months were analyzed and compared between the two groups. Out of 155 patients, 33 (21.29%) were elderly. Acute-on-chronic liver failure (ACLF) as the presentation was more common in elderly as compared to young AIH patients (39.4% vs. 13.9%, AIH is an important differential diagnosis among the elderly population presenting with ACLF and cirrhosis. When given appropriate immunosuppressants they have a similar outcome as compared to the youngest population.
Identifiants
pubmed: 32166119
doi: 10.5114/ceh.2020.93051
pii: 39898
pmc: PMC7062115
doi:
Types de publication
Journal Article
Langues
eng
Pagination
13-19Informations de copyright
Copyright: © 2020 Clinical and Experimental Hepatology.
Déclaration de conflit d'intérêts
The authors report no conflict of interest.
Références
QJM. 1997 Apr;90(4):289-96
pubmed: 9307764
Dig Dis Sci. 1985 Sep;30(9):824-8
pubmed: 3875463
J Hepatol. 2006 Oct;45(4):575-83
pubmed: 16899323
J Clin Gastroenterol. 2017 Jul;51(6):548-556
pubmed: 28272079
Hepatology. 2010 Jun;51(6):2193-213
pubmed: 20513004
Trop Gastroenterol. 2015 Jan-Mar;36(1):36-45
pubmed: 26591953
Hepatology. 1991 Apr;13(4):701-6
pubmed: 2010165
Hepatology. 2003 Dec;38(6):1596-601
pubmed: 14647073
Aliment Pharmacol Ther. 2005 Mar 15;21(6):695-9
pubmed: 15771755
Age Ageing. 1997 Nov;26(6):441-4
pubmed: 9466294
J Hepatol. 1999 Nov;31(5):929-38
pubmed: 10580593
Aliment Pharmacol Ther. 2005 May 15;21(10):1273-7
pubmed: 15882249
Clin Liver Dis. 2002 Aug;6(3):707-25
pubmed: 12362576
Am J Gastroenterol. 2001 May;96(5):1587-91
pubmed: 11374704
Aliment Pharmacol Ther. 2014 Jan;39(2):117-24
pubmed: 24261965
J Gastroenterol Hepatol. 2016 Oct;31(10):1742-1749
pubmed: 26989861