The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex.
Acute Brain slice Patch technique
Ca(2+)- dependent Activator Protein for Secretion (CAPS)
Optogenetic Stimulation
Sensory Adaptation
Synaptic Vesicle Priming
Visual Cortex
in-vivo patch clamp technique
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
10 03 2020
10 03 2020
Historique:
received:
07
12
2018
revised:
22
10
2019
accepted:
10
02
2020
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
24
3
2021
Statut:
ppublish
Résumé
Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control and sensory adaptation. Neurons employ synaptic vesicle priming proteins of the CAPS and Munc13 families to shape short-term plasticity in vitro, but the relevance of this phenomenon for information processing in the intact brain is unknown. By combining sensory stimulation with in vivo patch-clamp recordings in anesthetized mice, we show that genetic deletion of CAPS-1 in thalamic neurons results in more rapid adaptation of sensory-evoked subthreshold responses in layer 4 neurons of the primary visual cortex. Optogenetic experiments in acute brain slices further reveal that the enhanced adaptation is caused by more pronounced short-term synaptic depression. Our data indicate that neurons engage CAPS-family priming proteins to shape short-term plasticity for optimal sensory information transfer between thalamic and cortical neurons in the intact brain in vivo.
Identifiants
pubmed: 32160535
pii: S2211-1247(20)30206-0
doi: 10.1016/j.celrep.2020.02.045
pii:
doi:
Substances chimiques
Cadps protein, mouse
0
Calcium-Binding Proteins
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3261-3269.e4Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests All authors declare no competing interests.