N 1-methyladenosine (m1A) RNA modification: the key to ribosome control.
Journal
Journal of biochemistry
ISSN: 1756-2651
Titre abrégé: J Biochem
Pays: England
ID NLM: 0376600
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
received:
29
01
2020
accepted:
20
02
2020
pubmed:
5
3
2020
medline:
8
1
2021
entrez:
5
3
2020
Statut:
ppublish
Résumé
RNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply implicated in the topology or function of the two classes of RNA. In this commentary article, we would like to deal with the functional significance of m1A in RNA, and also to describe one methyltransferase installing m1A in a large subunit rRNA, whose orthologue in Caenorhabditis elegans was discovered recently and was reported in this journal.
Identifiants
pubmed: 32129871
pii: 5780289
doi: 10.1093/jb/mvaa026
doi:
Substances chimiques
RNA, Ribosomal
0
RNA, ribosomal, 26S
0
1-methyladenosine
15763-06-1
RNA, Transfer
9014-25-9
Methyltransferases
EC 2.1.1.-
Adenosine
K72T3FS567
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
535-539Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.