Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey.
Adenocarcinoma
/ epidemiology
Adolescent
Adult
Aged
Aged, 80 and over
Cystadenoma, Mucinous
/ epidemiology
Cystadenoma, Serous
/ epidemiology
Endosonography
Female
Humans
Italy
/ epidemiology
Magnetic Resonance Imaging
Male
Middle Aged
Neuroendocrine Tumors
/ epidemiology
Pancreas
/ diagnostic imaging
Pancreatic Neoplasms
/ epidemiology
Practice Guidelines as Topic
Prospective Studies
Surveys and Questionnaires
Young Adult
Biomarkers
Cystic neoplasm
Cytology
Endosonography
Epidemiology
Magnetic resonance imaging
Multidetector computed tomography
Pancreatic cyst
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
23
11
2019
revised:
07
02
2020
accepted:
09
02
2020
pubmed:
4
3
2020
medline:
12
5
2021
entrez:
4
3
2020
Statut:
ppublish
Résumé
A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines. An online data sheet was built. Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up. This prospective study offers a reliable real-life picture of the diagnostic work-up CPN.
Identifiants
pubmed: 32122771
pii: S1590-8658(20)30048-7
doi: 10.1016/j.dld.2020.02.003
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
547-554Informations de copyright
Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.