The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation.
hypocretin
inflammation
lateral hypothalamus
orexin
pain
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
09
2019
accepted:
24
01
2020
entrez:
3
3
2020
pubmed:
3
3
2020
medline:
3
3
2020
Statut:
epublish
Résumé
The roles of the hypothalamus and particularly the lateral hypothalamus (LH) in the regulation of inflammation and pain have been widely studied. The LH consists of a parasympathetic area that has connections with all the major parts of the brain. It controls the autonomic nervous system (ANS), regulates feeding behavior and wakeful cycles, and is a part of the reward system. In addition, it contains different types of neurons, most importantly the orexin neurons. These neurons, though few in number, perform critical functions such as inhibiting pain transmission and interfering with the reward system, feeding behavior and the hypothalamic pituitary axis (HPA). Recent evidence has identified a new role for orexin neurons in the modulation of pain transmission associated with several inflammatory diseases, including rheumatoid arthritis and ulcerative colitis. Here, we review recent findings on the various physiological functions of the LH with special emphasis on the orexin/receptor system and its role in mediating inflammatory pain.
Identifiants
pubmed: 32116534
doi: 10.3389/fnins.2020.00101
pmc: PMC7029733
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
101Informations de copyright
Copyright © 2020 Fakhoury, Salman, Najjar, Merhej and Lawand.
Références
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
J Comp Neurol. 2003 Oct 27;465(4):593-603
pubmed: 12975818
Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3618-3628
pubmed: 30251681
Neurosci Lett. 2003 Aug 28;347(3):183-6
pubmed: 12875916
Biomed Pharmacother. 2017 Jun;90:187-193
pubmed: 28360013
Peptides. 2005 May;26(5):767-77
pubmed: 15808907
J Neurosci. 1998 May 15;18(10):3489-500
pubmed: 9570780
Masui. 2007 Jan;56(1):40-7
pubmed: 17243644
Brain Res. 2008 Jun 12;1214:40-9
pubmed: 18457815
Front Behav Neurosci. 2010 Oct 20;4:53
pubmed: 21060718
J Neurophysiol. 1994 Mar;71(3):959-80
pubmed: 8201436
Nature. 1998 Dec 17;396(6712):670-4
pubmed: 9872314
Neuropharmacology. 2016 Nov;110(Pt A):15-24
pubmed: 27395784
Cell. 1998 Mar 6;92(5):1 page following 696
pubmed: 9527442
Int J Neuropsychopharmacol. 2017 May 1;20(5):403-409
pubmed: 28031268
Peptides. 1990 Sep-Oct;11(5):995-1001
pubmed: 1704616
Brain Res. 1978 May 5;146(1):123-40
pubmed: 647383
Eur J Pharmacol. 2003 Aug 15;475(1-3):37-47
pubmed: 12954357
Brain Res. 2018 Jul 1;1690:89-95
pubmed: 29630859
Nat Neurosci. 2016 Feb;19(2):198-205
pubmed: 26814589
Sci Rep. 2016 Jul 07;6:29480
pubmed: 27385517
Regul Pept. 2002 Mar 15;104(1-3):105-10
pubmed: 11830284
Pharmacol Biochem Behav. 2013 Apr;105:193-8
pubmed: 23474374
Brain Res. 1998 Sep 14;805(1-2):1-19
pubmed: 9733903
J Comp Neurol. 1998 Jun 15;395(4):535-47
pubmed: 9619505
J Neurosci. 2015 Mar 4;35(9):4005-14
pubmed: 25740528
Behav Brain Funct. 2007 Jun 13;3:28
pubmed: 17567902
J Pain. 2011 Feb;12(2):280-7
pubmed: 21145791
Front Endocrinol (Lausanne). 2017 Jun 12;8:101
pubmed: 28659864
Neurobiol Learn Mem. 2017 Dec;146:21-30
pubmed: 29107703
Int Rev Neurobiol. 2017;136:199-237
pubmed: 29056152
Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):353-60
pubmed: 12806206
West J Nurs Res. 2016 Mar;38(3):292-307
pubmed: 26475681
Neurobiol Learn Mem. 2016 Dec;136:183-188
pubmed: 27746379
Curr Pain Headache Rep. 2010 Jun;14(3):213-20
pubmed: 20461476
Neurology. 2002 Feb 12;58(3):498-9
pubmed: 11839864
J Neurosci. 2003 Mar 1;23(5):1557-62
pubmed: 12629156
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10720-E10729
pubmed: 30348772
J Inflamm Res. 2018 May 08;11:179-192
pubmed: 29773951
Front Neural Circuits. 2016 Aug 25;10:66
pubmed: 27610076
J Comp Neurol. 2001 May 28;434(2):158-85
pubmed: 11331523
Front Physiol. 2018 Jun 04;9:670
pubmed: 29915544
Mol Neurobiol. 2004 Feb;29(1):41-59
pubmed: 15034222
Neurosci Biobehav Rev. 1993 Summer;17(2):141-93
pubmed: 8515901
Front Neurosci. 2014 Feb 11;8:20
pubmed: 24574957
Neurology. 2001 Dec 26;57(12):2253-8
pubmed: 11756606
Endocrine. 2015 Nov;50(2):276-91
pubmed: 26089260
J Neurosci. 2002 Oct 15;22(20):8850-9
pubmed: 12388591
Brain Res. 2000 Mar 24;859(2):404-9
pubmed: 10719096
Br J Pharmacol. 2002 Sep;137(2):170-6
pubmed: 12208773
Cell Metab. 2009 Aug;10(2):89-98
pubmed: 19656487
Can J Physiol Pharmacol. 2014 Oct;92(10):813-20
pubmed: 25211278
Neuroscience. 2009 Apr 10;159(4):1414-21
pubmed: 19409203
Behav Brain Res. 1997 Feb;83(1-2):97-105
pubmed: 9062667
Nat Neurosci. 2018 Aug;21(8):1084-1095
pubmed: 30038273
Neuroreport. 2001 Mar 5;12(3):547-51
pubmed: 11234761
J Neurosci. 2004 Dec 15;24(50):11439-48
pubmed: 15601950
Dis Model Mech. 2017 Jun 1;10(6):679-689
pubmed: 28592656
Rev Neurosci. 2014;25(5):621-30
pubmed: 24887956
Neuropharmacology. 2016 Jun;105:577-586
pubmed: 26907809
Eur J Neurosci. 2004 Mar;19(6):1524-34
pubmed: 15066149
J Neurol Sci. 2016 Mar 15;362:106-10
pubmed: 26944127
Vitam Horm. 2012;89:185-208
pubmed: 22640614
Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E999-1011
pubmed: 23482448
Peptides. 2007 Mar;28(3):650-6
pubmed: 17161886
Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E13-7
pubmed: 12485808
Nat Commun. 2015 Feb 19;6:6266
pubmed: 25695914
J Inflamm Res. 2014 Jun 23;7:113-20
pubmed: 25075198
Pharmacol Ther. 2002 Apr-May;94(1-2):51-61
pubmed: 12191593
Iran J Pharm Res. 2016 Fall;15(4):851-859
pubmed: 28243282
Neurosci Lett. 2015 Sep 25;605:34-8
pubmed: 26275349
Biol Psychiatry. 2010 Apr 15;67(8):753-60
pubmed: 20189166
Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1159-85
pubmed: 16874931
Neurosci Lett. 2000 Jul 14;288(2):87-90
pubmed: 10876067
Neuroreport. 2001 Feb 12;12(2):435-40
pubmed: 11209963
Peptides. 1986 Jul-Aug;7(4):609-13
pubmed: 2429289
Pain. 2014 Jun;155(6):1128-39
pubmed: 24607959
Neuroreport. 2005 Jan 19;16(1):5-8
pubmed: 15618879
Endocrinology. 2018 Sep 1;159(9):3158-3176
pubmed: 30010830
J Neurosci. 2017 Jun 21;37(25):6053-6065
pubmed: 28539422
Neurol Sci. 2019 May;40(5):1067-1070
pubmed: 30645749
Cell. 2015 Jan 29;160(3):516-27
pubmed: 25635459
Neurosci Lett. 1999 Jan 15;259(3):153-6
pubmed: 10025581
Nat Neurosci. 2019 Feb;22(2):218-228
pubmed: 30643295
J Neurosci. 2016 Jan 13;36(2):302-11
pubmed: 26758824
Brain Res Bull. 1991 Sep-Oct;27(3-4):347-51
pubmed: 1959029
Dialogues Clin Neurosci. 2006;8(4):383-95
pubmed: 17290797
Compr Physiol. 2016 Mar 15;6(2):603-21
pubmed: 27065163
Behav Brain Res. 2016 Jan 1;296:431-441
pubmed: 26515931
Front Neuroendocrinol. 2003 Jul;24(3):141-50
pubmed: 14596809
J Comp Neurol. 2001 Jun 18;435(1):6-25
pubmed: 11370008
Neuroscience. 2017 Apr 21;348:313-323
pubmed: 28257896
Neurosurgery. 2016 Aug;63 Suppl 1:118-126
pubmed: 27399376
Psychoneuroendocrinology. 2017 Apr;78:168-176
pubmed: 28209543
Front Endocrinol (Lausanne). 2013 Mar 06;4:18
pubmed: 23508038
Peptides. 1999 Dec;20(12):1455-70
pubmed: 10698122
Ann N Y Acad Sci. 2008;1129:275-86
pubmed: 18591488
Neuroreport. 2018 Feb 7;29(3):224-228
pubmed: 29293172
J Neurosci. 2013 May 1;33(18):7618-26
pubmed: 23637156
Sleep. 2006 Oct;29(10):1327-36
pubmed: 17068987
Physiol Behav. 2011 Jul 25;104(1):29-39
pubmed: 21549732
J Neurosci. 2011 Oct 12;31(41):14600-10
pubmed: 21994376
Brain Res. 1987 Feb 17;403(2):290-300
pubmed: 2881607
Neuropharmacology. 2019 Aug;154:68-78
pubmed: 30266600
Nat Commun. 2018 Jan 4;9(1):52
pubmed: 29302029
J Neurosci. 1999 Apr 15;19(8):3171-82
pubmed: 10191330
J Neurosci. 2015 Jul 22;35(29):10387-9
pubmed: 26203134
Eur J Pharmacol. 2003 Nov 28;481(2-3):175-80
pubmed: 14642783
Brain Res. 2005 May 17;1044(1):76-86
pubmed: 15862792
J Neurosci. 2016 Mar 9;36(10):2975-85
pubmed: 26961951
J Immunol. 2017 Sep 1;199(5):1543-1552
pubmed: 28827386
J Neuroinflammation. 2019 Mar 20;16(1):64
pubmed: 30894198
PLoS Biol. 2019 Mar 20;17(3):e3000172
pubmed: 30893297
J Physiol. 2001 May 15;533(Pt 1):237-52
pubmed: 11351031
Neuroscience. 1986 Jun;18(2):395-402
pubmed: 2426632
Neurobiol Aging. 2016 Apr;40:120-126
pubmed: 26973111
Dialogues Clin Neurosci. 2002 Mar;4(1):31-46
pubmed: 22033745
Neuroscience. 1978;3(10):861-943
pubmed: 366451
Mol Metab. 2018 Jul;13:83-89
pubmed: 29843980
PLoS One. 2015 Nov 13;10(11):e0142919
pubmed: 26565961
Brain. 2007 Jun;130(Pt 6):1577-85
pubmed: 17470494
Mol Metab. 2015 Jul 16;4(10):706-17
pubmed: 26500842
J Physiol. 2016 Nov 15;594(22):6443-6462
pubmed: 27302606
Neuron. 2012 Oct 4;76(1):130-41
pubmed: 23040811
Front Physiol. 2017 May 31;8:357
pubmed: 28620314
Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R494-9
pubmed: 12557891
Synapse. 2008 Jul;62(7):516-23
pubmed: 18435418
Intern Med. 2003 Aug;42(8):743-5
pubmed: 12924505
Int Anesthesiol Clin. 2007 Spring;45(2):27-37
pubmed: 17426506
Front Cell Neurosci. 2015 Sep 04;9:348
pubmed: 26388735
Neurobiol Aging. 2012 Aug;33(8):1642-50
pubmed: 21546124
J Neuroendocrinol. 2008 Feb;20(2):199-206
pubmed: 18088361
Best Pract Res Clin Rheumatol. 2009 Feb;23(1):59-69
pubmed: 19233046
Hum Mol Genet. 2005 Jan 1;14(1):39-47
pubmed: 15525658
Front Syst Neurosci. 2017 Jul 06;11:50
pubmed: 28729827
Neuroscience. 2001;103(3):777-97
pubmed: 11274794
J Neurol. 2006 Sep;253(9):1232-3
pubmed: 16598614
Nature. 1996 Mar 21;380(6571):243-7
pubmed: 8637571
Brain Res. 1989 Dec 29;505(2):311-5
pubmed: 2480836
Science. 2013 Sep 27;341(6153):1517-21
pubmed: 24072922
Iran J Basic Med Sci. 2015 Dec;18(12):1183-8
pubmed: 26877847
Neurology. 2003 Aug 26;61(4):540-3
pubmed: 12939433
Brain Res Bull. 2000 Aug;52(6):491-7
pubmed: 10974488
Neuroscience. 2003;119(4):1033-44
pubmed: 12831862
Physiol Behav. 2007 Aug 15;91(5):479-85
pubmed: 17223141
Biol Res Nurs. 2009 Apr;10(4):331-9
pubmed: 19114413
J Neurol. 2017 Nov;264(11):2215-2223
pubmed: 28900724
FEBS Lett. 1998 Oct 30;438(1-2):71-5
pubmed: 9821961
PLoS One. 2016 Apr 08;11(4):e0152458
pubmed: 27058360
J Physiol Sci. 2018 Nov;68(6):717-722
pubmed: 30003408
Neuroscience. 2011 Oct 13;193:10-20
pubmed: 21821102
Cell Rep. 2017 Dec 12;21(11):3116-3128
pubmed: 29241540
J Neurosci. 2018 Feb 7;38(6):1588-1599
pubmed: 29311142
Cell J. 2014 Summer;16(2):131-40
pubmed: 24567942
J Neurosci. 2001 Oct 1;21(19):RC168
pubmed: 11567079
Proc Natl Acad Sci U S A. 1970 Oct;67(2):1063-70
pubmed: 4399738
Neurology. 2014 Jan 21;82(3):271-8
pubmed: 24363130
Biomed Pharmacother. 2018 Nov;107:763-768
pubmed: 30142537
J Alzheimers Dis. 2012;29(1):125-32
pubmed: 22207004
Front Syst Neurosci. 2018 Apr 16;12:14
pubmed: 29713268
Curr Biol. 2017 Jul 24;27(14):2089-2100.e5
pubmed: 28690111
Neuron. 2016 Mar 16;89(6):1291-1304
pubmed: 26948889
Neuron. 2006 Sep 21;51(6):801-10
pubmed: 16982424
Eur J Pain. 2016 Aug;20(7):1090-101
pubmed: 26871274
Alcohol Res. 2012;34(4):468-83
pubmed: 23584113
Curr Opin Pharmacol. 2009 Dec;9(6):787-93
pubmed: 19758844
Peptides. 2009 Nov;30(11):2025-30
pubmed: 19463877
Pain. 2001 May;92(1-2):81-90
pubmed: 11323129