Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review.
adherence
fixed-dose combination
polypill
systematic review
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
22 Feb 2020
22 Feb 2020
Historique:
received:
17
01
2020
revised:
19
02
2020
accepted:
20
02
2020
entrez:
27
2
2020
pubmed:
27
2
2020
medline:
27
2
2020
Statut:
epublish
Résumé
Many patients, especially those with a high pill burden and multiple chronic illnesses, are less adherent to medication. In medication treatments utilizing polypills, this problem might be diminished since multiple drugs are fused into one formulation and, therefore, the therapy regimen is simplified. This systematic review summarized evidence to assess the effect of polypills on medication adherence. The following databases were searched for articles published between 1 January 2000, and 14 May 2019: PubMed, Web of Science, Cochrane Library, and Scopus. Medication adherence was the only outcome assessed, regardless of the method of measuring it. Sixty-seven original peer-reviewed articles were selected. Adherence to polypill regimens was significantly higher in 56 articles (84%) compared to multiple pill regimens. This finding was also supported by the results of 13 out of 17 selected previously published systematic reviews and meta-analyses dealing with this topic. Adherence can be improved through the formulation of polypills, which is probably why the interest in researching them is growing. There are many polypills on the market, but the adherence studies so far focused mainly on a small range of medical conditions.
Identifiants
pubmed: 32098393
pii: pharmaceutics12020190
doi: 10.3390/pharmaceutics12020190
pmc: PMC7076630
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Curr Med Res Opin. 2010 Sep;26(9):2065-76
pubmed: 20629600
Ann Pharmacother. 2006 Jul-Aug;40(7-8):1274-9
pubmed: 16849622
Clin Ther. 2012 Mar;34(3):712-9
pubmed: 22381712
Medicine (Baltimore). 2015 Oct;94(42):e1677
pubmed: 26496277
J Clin Hypertens (Greenwich). 2018 May;20(5):902-907
pubmed: 29700923
Public Health. 2014 Jan;128(1):70-6
pubmed: 23969148
Patient Prefer Adherence. 2013 Jul 10;7:675-82
pubmed: 23874088
Patient Prefer Adherence. 2019 Jan 31;13:241-248
pubmed: 30774320
J Clin Hypertens (Greenwich). 2018 Dec;20(12):1731-1738
pubmed: 30375168
Clinicoecon Outcomes Res. 2014 Apr 22;6:209-16
pubmed: 24790462
AIDS Patient Care STDS. 2017 Sep;31(9):370-376
pubmed: 28771023
Am J Cardiovasc Drugs. 2008;8(1):45-50
pubmed: 18303937
Pharmaceutics. 2019 Jun 11;11(6):
pubmed: 31212649
J Med Econ. 2011;14(5):576-83
pubmed: 21728914
Clin Ther. 2004 Dec;26(12):2066-75
pubmed: 15823770
Int J Clin Pract. 2017 Aug;71(8):
pubmed: 28722790
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
J Int Assoc Provid AIDS Care. 2015 Jan-Feb;14(1):64-71
pubmed: 25331217
Heart. 2019 Jan;105(1):42-48
pubmed: 29954855
AIDS Care. 2005 Nov;17(8):938-48
pubmed: 16176890
Circ J. 2012;76(6):1415-22
pubmed: 22447014
Ther Innov Regul Sci. 2017 Jan;51(1):111-117
pubmed: 30235996
Int J Cardiol. 2015 Feb 15;181:193-9
pubmed: 25528311
Ann Pharmacother. 2010 May;44(5):791-9
pubmed: 20371759
Br J Clin Pharmacol. 2017 Jan;83(1):202-210
pubmed: 27517705
Curr Med Res Opin. 2010 Dec;26(12):2877-87
pubmed: 21067459
High Blood Press Cardiovasc Prev. 2012 Jun 1;19(2):51-4
pubmed: 22867089
Eur Respir J. 2013 Sep;42(3):721-32
pubmed: 23314904
Cochrane Database Syst Rev. 2017 Mar 06;3:CD009868
pubmed: 28263370
J Control Release. 2015 Nov 10;217:308-14
pubmed: 26390808
Patient Prefer Adherence. 2019 Apr 03;13:475-490
pubmed: 31040651
Curr Hypertens Rep. 2007 Jun;9(3):184-9
pubmed: 17519122
Int J Cardiol. 2016 Feb 15;205:147-156
pubmed: 26736090
Curr Med Res Opin. 2011 Jun;27(6):1157-68
pubmed: 21466277
Curr Med Res Opin. 2012 Jun;28(6):969-77
pubmed: 22494018
Curr Med Res Opin. 2018 Sep;34(9):1571-1577
pubmed: 29376432
J Am Coll Cardiol. 2014 Nov 18-25;64(20):2071-82
pubmed: 25193393
PLoS Med. 2018 Jun 11;15(6):e1002584
pubmed: 29889841
Pharmacotherapy. 2016 Apr;36(4):385-401
pubmed: 26923931
HIV Med. 2014 May;15(5):286-90
pubmed: 24215485
Nat Rev Cardiol. 2013 Dec;10(12):683-4
pubmed: 24101102
J Clin Hypertens (Greenwich). 2011 Dec;13(12):898-909
pubmed: 22142349
Pharmacoepidemiol Drug Saf. 2017 Dec;26(12):1465-1473
pubmed: 29067759
PLoS One. 2016 Aug 22;11(8):e0161285
pubmed: 27548060
Patient Prefer Adherence. 2010 May 13;4:115-25
pubmed: 20517472
J Antimicrob Chemother. 2015 Jul;70(7):2121-8
pubmed: 25904729
J Med Econ. 2016;19(3):203-12
pubmed: 26473990
Hypertension. 2010 Feb;55(2):399-407
pubmed: 20026768
Am J Health Syst Pharm. 2007 Jun;64(12):1279-83
pubmed: 17563050
Int J STD AIDS. 2012 May;23(5):351-5
pubmed: 22648890
BMJ. 2014 May 27;348:g3318
pubmed: 24868083
Drugs. 1982 Jun;23(6):462-80
pubmed: 7049658
Patient Prefer Adherence. 2009 Nov 03;3:265-75
pubmed: 19936170
JAMA. 2013 Sep 4;310(9):918-29
pubmed: 24002278
Vasc Health Risk Manag. 2008;4(3):673-81
pubmed: 18827917
Curr Med Res Opin. 2015 Dec;31(12):2287-96
pubmed: 26397178
Trop Med Int Health. 2014 May;19(5):501-13
pubmed: 24628918
Clin Ther. 2011 Sep;33(9):1281-8
pubmed: 21840054
Eur J Prev Cardiol. 2015 Jul;22(7):920-30
pubmed: 24676715
Am J Med. 2007 Aug;120(8):713-9
pubmed: 17679131
Am J Cardiovasc Drugs. 2010;10(3):193-202
pubmed: 20387911
Ann Behav Med. 2017 Feb;51(1):67-78
pubmed: 27510955
Clin Exp Hypertens. 2013;35(5):355-60
pubmed: 23072348
Clin Ther. 2002 Mar;24(3):460-7
pubmed: 11952029
Am J Manag Care. 2016 Apr;22(4):242-8
pubmed: 27143289
AIDS. 2010 Nov 27;24(18):2835-40
pubmed: 21045636
Lancet. 2002 Nov 2;360(9343):1347-60
pubmed: 12423980
Curr Med Res Opin. 2008 Sep;24(9):2597-607
pubmed: 18812017
J Am Soc Hypertens. 2013 Jan-Feb;7(1):46-60
pubmed: 23321404
Cochrane Database Syst Rev. 2014 Nov 20;(11):CD000011
pubmed: 25412402
Am J Cardiol. 2005 Nov 7;96(9A):28K-33K; discussion 34K-35K
pubmed: 16291011
BMJ. 2011 Oct 18;343:d5928
pubmed: 22008217
AIDS Res Treat. 2014;2014:967073
pubmed: 25276422
BMJ Open. 2013 Aug 01;3(8):
pubmed: 23906955
Hypertension. 2014 May;63(5):958-67
pubmed: 24446059
J Clin Hypertens (Greenwich). 2018 Apr;20(4):705-715
pubmed: 29457348
Curr Med Res Opin. 2011 May;27(5):961-8
pubmed: 21381893
Ethn Dis. 2008 Spring;18(2):204-9
pubmed: 18507275
Diabetes Obes Metab. 2003 Nov;5(6):424-31
pubmed: 14617228
BMC Urol. 2017 May 22;17(1):36
pubmed: 28532455
Int J Endocrinol. 2015;2015:251485
pubmed: 26089879
Curr Med Res Opin. 2014 Dec;30(12):2415-22
pubmed: 25222764
Clin Drug Investig. 2014 Jun;34(6):403-11
pubmed: 24719291
J Clin Hypertens (Greenwich). 2016 Sep;18(9):934-41
pubmed: 26917089
Congest Heart Fail. 2003 Nov-Dec;9(6):324-32
pubmed: 14688505
J Clin Hypertens (Greenwich). 2015 Jan;17(1):51-8
pubmed: 25477188
J Gen Intern Med. 2008 May;23(5):611-4
pubmed: 18288541
Int J Clin Pract. 2015 Jul;69(7):729-37
pubmed: 25395349
J Manag Care Spec Pharm. 2016 Mar;22(3):255-62
pubmed: 27003555
Curr Med Res Opin. 2009 Nov;25(11):2765-75
pubmed: 19785511
Clin Ther. 2008 Oct;30(10):1893-907
pubmed: 19014846
AIDS Res Ther. 2018 Oct 30;15(1):17
pubmed: 30373620
Patient Prefer Adherence. 2018 Apr 24;12:625-635
pubmed: 29731610
J Clin Hypertens (Greenwich). 2017 Oct;19(10):983-989
pubmed: 28560786
J Gen Intern Med. 2017 Jun;32(6):619-625
pubmed: 28050754
Arch Med Sci. 2018 Aug;14(5):1125-1136
pubmed: 30154897
P T. 2008 Nov;33(11):652-66
pubmed: 19750061
Heart Asia. 2017 Jun 26;9(2):e010885
pubmed: 29467832