The Quebec Low Back Pain Study: a protocol for an innovative 2-tier provincial cohort.

acute chronic inception cohort low back pain persistence two-stage sampling

Journal

Pain reports
ISSN: 2471-2531
Titre abrégé: Pain Rep
Pays: United States
ID NLM: 101683899

Informations de publication

Date de publication:
Historique:
received: 08 07 2019
revised: 02 10 2019
accepted: 24 10 2019
entrez: 20 2 2020
pubmed: 20 2 2020
medline: 20 2 2020
Statut: epublish

Résumé

The neurobiological mechanisms underlying recovery from or persistence of low back pain (LBP) remain misunderstood, limiting progress toward effective management. We have developed an innovative two-tier design to study the transition from acute to chronic LBP. The objective of the first tier is to create a provincial web-based infrastructure to recruit and monitor the trajectory of individuals with acute LBP. The objective of the second tier is to fuel hypothesis-driven satellite data collection centers with specialized expertise to study the role of biomechanical, epigenetic, genetic, neuroanatomical, ontological, physiological, psychological, and socioeconomic factors in LBP chronicity. This article describes the first tier of the protocol: establishment of the Core Dataset and Cohort. Adults with acute LBP will be recruited through networks, media, and health care settings. A web-based interface will be used to collect self-reported variables at baseline and at 3, 6, 12, and 24 months. Acute LBP will be defined according to the Dionne 2008 consensus. Measurements will include the Canadian minimum data set for chronic LBP research, DN4 for neuropathic pain, comorbidities, EQ-5D-5L for quality of life, and linkage with provincial medico-administrative databases. The primary outcome will be the transition to chronic LBP, as defined by Deyo 2014. Secondary outcomes include health care resource utilization, disability, sick leave, mood, and quality of life. This study brings together diverse research expertise to investigate the transition from acute to chronic LBP, characterize the progression to recovery or chronicity, and identify patterns associated with that progression.

Identifiants

DOI: 10.1097/PR9.0000000000000799 PMID: 32072095 PMC: PMC7004506
pubmed: 32072095
doi: 10.1097/PR9.0000000000000799
pii: PAINREPORTS-D-19-0102
pmc: PMC7004506
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e799

Informations de copyright

Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

Déclaration de conflit d'intérêts

L. Diatchenko and F. Montagna report grant SCA145102 from the Strategy for Patient Oriented Research (SPOR) during the conduct of the study. L.S. Stone reports grants and nonfinancial support from Quebec Pain Research Network during the conduct of the study. The remaining authors have no conflicts of interest to declare. Previous presentations: Quebec Pain Research Network Annual General Meeting November 2017—Project update, Quebec Pain Research Network Annual General Meeting January 2019—Project update, Canadian Pain Network Biomarkers Meeting—January 2019—Project overview.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

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Auteurs

Gabrielle M Pagé (GM)

Department of Anesthesiology and Pain Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.

Anaïs Lacasse (A)

Départment des sciences de la santé, Université du Québec en Abitibi-Témiscamingue, QC, Canada.

Nicolas Beaudet (N)

Quebec Pain Research Network, QC, Canada.
Department of Anesthesiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
Centre de recherche du Centre hospitalier de l'Université de Sherbrooke (CRCHUS), Sherbrooke, QC, Canada.

Manon Choinière (M)

Department of Anesthesiology and Pain Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.

Simon Deslauriers (S)

Center for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS, CIUSSS-CN), Quebec City, QC, Canada.
Department of Rehabilitation, Faculty of Medicine, Université Laval, Quebec City, QC, Canada.

Luda Diatchenko (L)

Alan Edwards Centre for Research on Pain, McGill University Health Centre (MUHC), QC, Canada.
Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Laurent Dupuis (L)

Department of Anesthesiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.

Stéphanie Grégoire (S)

Alan Edwards Centre for Research on Pain, McGill University Health Centre (MUHC), QC, Canada.
Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Richard Hovey (R)

Alan Edwards Centre for Research on Pain, McGill University Health Centre (MUHC), QC, Canada.
Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Erwan Leclair (E)

Quebec Pain Research Network, QC, Canada.
Alan Edwards Centre for Research on Pain, McGill University Health Centre (MUHC), QC, Canada.

Guillaume Leonard (G)

School of Rehabilitation, Faculty of Medicine and Health Sciences, Research Center on Aging, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke (CIUSSS de l'Estrie-CHUS), Université de Sherbrooke, Sherbrooke, Québec, Canada.

Carolina B Meloto (CB)

Alan Edwards Centre for Research on Pain, McGill University Health Centre (MUHC), QC, Canada.
Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Francesca Montagna (F)

Alan Edwards Centre for Research on Pain, McGill University Health Centre (MUHC), QC, Canada.
Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Alexandre Parent (A)

Quebec Pain Research Network, QC, Canada.

Pierre Rainville (P)

Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-sud-de-l'île de Montréal, Montréal, QC, Canada.
Department of Stomatology, Université de Montréal, Montréal, QC, Canada.
Groupe de Recherche sur le Système Nerveux Central (GRSNC), and Centre de recherche en Neuropsychologie et Cognition (CERNEC), Université de Montréal, Montréal, QC, Canada.

Jean-Sébastien Roy (JS)

Center for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS, CIUSSS-CN), Quebec City, QC, Canada.
Department of Rehabilitation, Faculty of Medicine, Université Laval, Quebec City, QC, Canada.

Mathieu Roy (M)

Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-sud-de-l'île de Montréal, Montréal, QC, Canada.
Department of Psychology, Faculty of Science, McGill University, Montreal, QC, Canada.

Mark A Ware (MA)

Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-sud-de-l'île de Montréal, Montréal, QC, Canada.

Timothy H Wideman (TH)

Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-sud-de-l'île de Montréal, Montréal, QC, Canada.
School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montreal, QC, Canada.

Laura S Stone (LS)

Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-sud-de-l'île de Montréal, Montréal, QC, Canada.
Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Classifications MeSH