Correlation of gene expression profiling score, cardiac hemodynamics and echocardiographic parameters in asymptomatic, rejection-free pediatric heart transplant recipients.
Adolescent
Cardiac Catheterization
Child
Child, Preschool
Echocardiography
Female
Follow-Up Studies
Gene Expression Profiling
Graft Rejection
/ diagnosis
Heart Diseases
/ diagnosis
Heart Transplantation
Hemodynamics
/ genetics
Humans
Infant
Male
Postoperative Complications
/ diagnosis
Retrospective Studies
Transcriptome
acute cellular rejection
allomap gene expression profiling
cardiac allograft vasculopathy
pediatric heart transplantation
Journal
Pediatric transplantation
ISSN: 1399-3046
Titre abrégé: Pediatr Transplant
Pays: Denmark
ID NLM: 9802574
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
14
01
2020
accepted:
21
01
2020
pubmed:
19
2
2020
medline:
10
4
2021
entrez:
19
2
2020
Statut:
ppublish
Résumé
To correlate gene expression profiling scores obtained by AlloMap Single-institution retrospective study of 210 AlloMap scores obtained concomitantly with cardiac catheterization and echocardiogram from 55 children during follow-up after cardiac transplantation. The median age at HT was 5.1 years (range, 0.9-14.1), with 29 males and 26 females. AlloMap scores were high in <2 years vs ≥2 years of age at the time of HT (P = .001), and trending higher with time after HT (R Our study provides preliminary data that the AlloMap score must be studied carefully before it can be used in children, particularly in those under 2 years of age. Monitoring of serial scores for each patient could potentially reflect changes in allograft performance that may determine indications for catheterization and biopsy which needs to be validated in future studies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13673Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
Gossett JG, Canter CE, Zheng J, et al. Decline in rejection in the first year after pediatric cardiac transplantation: a multi-institutional study. J Heart Lung Transplant. 2010;29:625-632.
Hathout E, Beeson WL, Kuhn M, et al. Cardiac allograft vasculopathy in pediatric heart transplant recipients. Transpl Int. 2006;19:184-189.
Pophal SG, Sigfusson G, Booth KL, et al. Complications of endomyocardial biopsy in children. J Am Coll Cardiol. 1999;34:2105-2110.
Daly KP, Marshall AC, Vincent JA, et al. Endomyocardial biopsy and selective coronary angiography are low-risk procedures in pediatric heart transplant recipients: results of a multicenter experience. J Heart Lung Transplant. 2012;31:398-409.
Fang KC. Clinical utilities of peripheral blood gene expression profiling in the management of cardiac transplant patients. J Immunotoxicology. 2007;4:209-217.
Costanzo MR, Dipchand A, Starling R, et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29:914-956.
Deng MC, Eisen HJ, Mehra MR, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant. 2006;6:150-160.
Pham MX, Teuteberg JJ, Kfoury AG, et al. Gene expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med. 2010;362(20):1890-1900.
Sutton C, Butts R, Burnette A, et al. Gene expression monitoring in pediatric heart transplant recipients. Insight Pediatr Cardiol. 2016;1:1.
St Goar FG, Pinto FJ, Alderman EL, et al. Detection of coronary atherosclerosis in young adult hearts using intravascular ultrasounds. Circulation. 1992;86:756-763.
Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710-1720.
Zinn MD, Wallendrof MJ, Simpson KE, Osborne A, Kirklin JK, Canter CE. Impact of routine surveillance biopsy intensity on the diagnosis of moderate to severe cellular rejection and survival after pediatric transplantation. Pediatr Transplant. 2018;22(3):e13131.
Kobashigawa J, Patel J, Azarbal B, et al. Randomized pilot trial of gene expression profiling versus heart biopsy in the first year after heart transplantation. Early invasive monitoring attenuation through gene expression trial. Circ. Heart Failure. 2015;8:557-564.
Xin A, Lee MGY, Hu Y, et al. Identifying low-grade cellular rejection after heart transplantation in children by using gene expression profiling. Physiol Genomics. 2018;50:190-196.
Knecht KR, MacLeod SL, Hobbs CA, Li M, Morrow WR. Gene expression profiling in pediatric heart transplant rejection. Int J Cardiol. 2013;168:5052-5053.
Singh TP, Faber C, Blume E, et al. Safety and early outcomes using a corticosteroid-avoidance immunosuppression protocol in pediatric heart transplant patients. J Heart Lung Transplant. 2010;29:517-522.
St Goar FG, Gibbons R, Schnittger I, Valantine HA, Popp RL. Left ventricular diastolic function. Doppler echocardiographic changes soon after cardiac transplantation. Circulation. 1990;82:872-878.
Goland S, Siegel RJ, Burton K, et al. Changes in left and right ventricular function of donor hearts during first year after heart transplantation. Heart. 2011;97:1681-1686.
Yamani MH, Taylor DO, Rodriguez ER, et al. Transplant vasculopathy is associated with increased AlloMap gene expression score. J Heart Lung Transplant. 2007;26:403-406.