Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta.
Animals
Antihypertensive Agents
/ isolation & purification
Aorta, Thoracic
/ drug effects
Blood Pressure
/ drug effects
Calcium Channel Blockers
/ isolation & purification
Calcium Channels
/ metabolism
Female
Hexanes
/ chemistry
Hypertension
/ drug therapy
In Vitro Techniques
Plant Extracts
/ isolation & purification
Plant Leaves
/ chemistry
Primulaceae
/ chemistry
Rabbits
Vasodilation
/ drug effects
Journal
Pakistan journal of pharmaceutical sciences
ISSN: 1011-601X
Titre abrégé: Pak J Pharm Sci
Pays: Pakistan
ID NLM: 9426356
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
25
6
2020
Statut:
ppublish
Résumé
Hypertension is persistent elevation in blood pressure for 3-4 weeks. Estimated global prevalence of hypertension suggested that by the Year 2025 (29%) of adult worldwide are suffering from hypertension (1.56 billion). Hypertension complications are hemorrhage, atherosclerosis, renal artery stenosis, angina pectoris end organ damage, cardiomyopathy, myocardial infarction and retinopathy. Along with other drug class Calcium channel blocker are also used for the treatment of hypertension. In this study the possible action of the n-hexane leaves fraction of the Androsace foliosa on isolated rabbit aorta was examined. Antihypertensive activity was examined in the existence of standard agonist like phenylephrine and antagonist like Verapamil. Phenylephrine (PE 1μM) high K
Substances chimiques
Antihypertensive Agents
0
Calcium Channel Blockers
0
Calcium Channels
0
Hexanes
0
Plant Extracts
0
n-hexane
2DDG612ED8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM