Characterization of the human GnRH neuron developmental transcriptome using a

CRISPR-Associated Protein 9 / metabolism CRISPR-Cas Systems / genetics Cell Line Fetus / cytology Fibroblast Growth Factor 8 / pharmacology Genes, Reporter Gonadotropin-Releasing Hormone / metabolism Humans Hypogonadism / genetics LIM-Homeodomain Proteins / metabolism Neurons / drug effects Pluripotent Stem Cells / drug effects RNA, Messenger / genetics Transcription Factors / metabolism Transcriptome / genetics Up-Regulation / drug effects
GnRH neuron Human ISL1 Reporter Transcriptome hPSCs

Journal

Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332

Informations de publication

Date de publication:
13 03 2020
Historique:
received: 12 04 2019
accepted: 16 01 2020
pubmed: 31 1 2020
medline: 30 1 2021
entrez: 31 1 2020
Statut: epublish

Résumé

Gonadotropin-releasing hormone (GnRH) neurons provide a fundamental signal for the onset of puberty and subsequent reproductive functions by secretion of gonadotropin-releasing hormone. Their disrupted development or function leads to congenital hypogonadotropic hypogonadism (CHH). To model the development of human GnRH neurons, we generated a stable

Identifiants

DOI: 10.1242/dmm.040105 PMID: 31996360 PMC: PMC7075073
pubmed: 31996360
pii: dmm.040105
doi: 10.1242/dmm.040105
pmc: PMC7075073
pii:
doi:

Substances chimiques

LIM-Homeodomain Proteins 0
RNA, Messenger 0
Transcription Factors 0
insulin gene enhancer binding protein Isl-1 0
Fibroblast Growth Factor 8 148997-75-5
Gonadotropin-Releasing Hormone 33515-09-2
CRISPR-Associated Protein 9 EC 3.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2020. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

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Auteurs

Carina Lund (C)

Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Medicum, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-9050-3626

Venkatram Yellapragada (V)

Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Medicum, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.

Sanna Vuoristo (S)

Department of Obstetrics and Gynecology, 00029 Helsinki University Hospital, Helsinki, Finland.

Diego Balboa (D)

Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.

Sara Trova (S)

Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Center, U1172 Lille, France.

Cecile Allet (C)

Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Center, U1172 Lille, France.

Nazli Eskici (N)

Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Medicum, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.

Kristiina Pulli (K)

Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Medicum, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.

Paolo Giacobini (P)

Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Center, U1172 Lille, France.
University of Lille, FHU 1000 Days for Health, School of Medicine, 59000 Lille, France.

Timo Tuuri (T)

Department of Obstetrics and Gynecology, 00029 Helsinki University Hospital, Helsinki, Finland.

Taneli Raivio (T)

Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland taneli.raivio@helsinki.fi.
Medicum, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
New Children's Hospital, Pediatric Research Center, 00029 Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0001-5385-434X

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines associées aux CRISPR › Protéine-9 associée à CRISPR › Characterization of the human GnRH neuron...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Characterization of the human GnRH neuron...
Recherchemedicale.com › Cellules › Cellules cultivées › Lignée cellulaire › Characterization of the human GnRH neuron...
Recherchemedicale.com › Structures de l'embryon › Foetus › Characterization of the human GnRH neuron...
Recherchemedicale.com › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance fibroblastique › Facteur de croissance fibroblastique de type 8 › Characterization of the human GnRH neuron...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes rapporteurs › Characterization of the human GnRH neuron...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Hormone de libération des gonadotrophines › Characterization of the human GnRH neuron...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterization of the human GnRH neuron...
Recherchemedicale.com › Maladies endocriniennes › Troubles gonadiques › Hypogonadisme › Characterization of the human GnRH neuron...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines à domaine LIM › Protéines à homéodomaine LIM › Characterization of the human GnRH neuron...
Recherchemedicale.com › Cellules › Neurones › Characterization of the human GnRH neuron...
Recherchemedicale.com › Cellules › Cellules souches › Cellules souches pluripotentes › Characterization of the human GnRH neuron...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Characterization of the human GnRH neuron...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Characterization of the human GnRH neuron...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Transcriptome › Characterization of the human GnRH neuron...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Characterization of the human GnRH neuron...