"Shielding" of Cytokine Induction by the Periodontal Microbiome in Patients with Periodontitis Associated with Type 2 Diabetes Mellitus.
IL
bioplex
chemokines
chronic periodontitis
interleukins
periodontal pathogens
salivary cytokine profile
type 2 diabetes mellitus
Journal
Acta naturae
ISSN: 2075-8251
Titre abrégé: Acta Naturae
Pays: Russia (Federation)
ID NLM: 101525823
Informations de publication
Date de publication:
Historique:
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
30
1
2020
Statut:
ppublish
Résumé
Periodontal diseases, especially those with polymicrobial etiology, are often associated with type 2 diabetes mellitus, proceeding more severely and affecting the course of diabetes mellitus. Recently, this feature has been associated with the ability of periodontopathogen microflora to cause not only a local infectious process in the oral cavity, but also to interact with the human immune system and induce various systemic effects. We investigated changes in the salivary cytokine profile of patients with chronic periodontitis, associated and not associated with type 2 diabetes mellitus. We observed a statistically significant decrease of MCP-1/CCL2, GM-CSF, IL-5, IL-6, and IFN-γ in the saliva of patients with chronic periodontitis associated with type 2 diabetes mellitus in comparison with patients with chronic periodontitis only. All of these cytokines are associated with macrophage activation. These data are an important contribution to the elucidation of the mechanism of periodontopathogens involvement in the manifestation of the systemic effects of type 2 diabetes.
Identifiants
pubmed: 31993238
doi: 10.32607/20758251-2019-11-4-79-87
pmc: PMC6977959
doi:
Types de publication
Journal Article
Langues
eng
Pagination
79-87Informations de copyright
Copyright ® 2019 National Research University Higher School of Economics.
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