Acetaminophen
Allium jesdianum
Hepatotoxicity
Oxidative stress
Journal
Journal of pharmacopuncture
ISSN: 2093-6966
Titre abrégé: J Pharmacopuncture
Pays: Korea (South)
ID NLM: 101572812
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
01
03
2019
revised:
18
07
2019
accepted:
25
11
2019
entrez:
24
1
2020
pubmed:
24
1
2020
medline:
24
1
2020
Statut:
ppublish
Résumé
Allium jesdianum (Aj) is a medicinal plant that has highlighted pharmacological features. In this study, the effects of Aj extract were examined on acetaminophen (APAP)-induced hepatic failure in rats. Methanolic fraction of hydro-alcoholic extract of Aj was obtained by silica gel column chromatography method. Animals were randomly divided into four groups each containing six rats and treated by gavage as follows: the first and second groups received normal saline, the third and fourth groups were received with 50 and 100 mg/kg of Aj extract, respectively. After two consecutive weeks, the groups 2-4 were given a single dose of APAP (2 g/kg). After 48 hours, blood and liver samples were collected for biochemical and histological examinations. The findings of the study demonstrated that APAP caused a significant increase in ALT (P < 0.001), AST (P < 0.001), LDH (P < 0.001), ALP (P < 0.001) serum levels, hepatic lipid peroxidation (LPO; P < 0.001) and nitric oxide (NO; P < 0.001). In this regard, APAP led to the depletion of the total antioxidant capacity (TAC; P < 0.001), glutathione and total thiol groups (TTGs; P < 0.001), and structural change in the liver. In the Aj extract groups, a considerable improvement was found in the hepatic function alongside the histopathologic changes. This investigation indicated that the influential effects of Aj extract in APAP-induced hepatic failure might depend on its effect on improving oxidant/antioxidant balance in hepatic tissue.
Identifiants
pubmed: 31970021
doi: 10.3831/KPI.2019.22.032
pii: 2093-6966-v22-n04-239
pmc: PMC6970575
doi:
Types de publication
Journal Article
Langues
eng
Pagination
239-247Informations de copyright
© 2019 Korean Pharmacopuncture Institute.
Déclaration de conflit d'intérêts
Conflict of interest No conflicts of interest were declared by the authors.
Références
Drug Res (Stuttg). 2017 May;67(5):283-288
pubmed: 28561222
Food Chem. 2016 Nov 15;211:41-50
pubmed: 27283605
Food Chem Toxicol. 2015 Jun;80:193-200
pubmed: 25818464
Res Pharm Sci. 2018 Aug;13(4):368-376
pubmed: 30065770
J Tradit Complement Med. 2016 Feb 03;7(1):9-13
pubmed: 28053882
J Clin Hypertens (Greenwich). 2015 Mar;17(3):223-31
pubmed: 25557383
Pharmazie. 2011 May;66(5):378-81
pubmed: 21699073
Int Immunopharmacol. 2017 Jun;47:95-105
pubmed: 28376392
Iran J Med Sci. 2015 Jan;40(1):45-50
pubmed: 25650289
Drug Metab Rev. 2017 Nov;49(4):395-437
pubmed: 28766385
EXCLI J. 2018 Jan 08;17:57-71
pubmed: 29383019
Xenobiotica. 2017 Feb;47(2):164-175
pubmed: 27086508
Biol Trace Elem Res. 2017 Jan;175(1):136-145
pubmed: 27220627
Asian Pac J Trop Med. 2016 Mar;9(3):221-7
pubmed: 26972391
Evid Based Complement Alternat Med. 2017;2017:9402849
pubmed: 28261311
Biochem Med (Zagreb). 2011;21(1):79-85
pubmed: 22141211
Int J Prev Med. 2016 Jul 29;7:95
pubmed: 27563431
J Nephropharmacol. 2015 Jan 01;4(1):27-30
pubmed: 28197471
Iran J Pharm Res. 2015 Fall;14(4):1225-31
pubmed: 26664390
Genes Nutr. 2018 Dec 27;13:34
pubmed: 30607216
BMC Complement Altern Med. 2017 Aug 17;17(1):411
pubmed: 28818066
Arch Toxicol. 2017 Feb;91(2):761-773
pubmed: 27002509
J Clin Transl Hepatol. 2016 Jun 28;4(2):131-42
pubmed: 27350943
Gene Expr. 2018 Mar 21;18(1):19-30
pubmed: 29054140
Biomed Pharmacother. 2017 Feb;86:363-367
pubmed: 28011384
Environ Toxicol Pharmacol. 2016 Jul;45:274-81
pubmed: 27343752
Food Technol Biotechnol. 2017 Jun;55(2):266-275
pubmed: 28867958
Chem Res Toxicol. 2015 Sep 21;28(9):1796-802
pubmed: 26304691
Pharm Biol. 2015 Apr;53(4):571-81
pubmed: 25339313
Nat Prod Res. 2018 May;32(10):1193-1197
pubmed: 28475377
Pestic Biochem Physiol. 2018 Jun;148:16-21
pubmed: 29891368
Pharm Res. 2008 Oct;25(10):2231-42
pubmed: 18626753
Sci Pharm. 2017 Jan 26;85(1):
pubmed: 28134775
J Ethnopharmacol. 2015 Aug 22;172:202-13
pubmed: 26133062
Recent Pat Drug Deliv Formul. 2016;10(1):72-6
pubmed: 26517821
Crit Rev Food Sci Nutr. 2013;53(3):215-30
pubmed: 23215996
Hepatology. 1998 Mar;27(3):748-54
pubmed: 9500703
Complement Ther Med. 2019 Feb;42:223-225
pubmed: 30670245
Food Chem. 2016 Apr 15;197(Pt A):829-35
pubmed: 26617023
Res Pharm Sci. 2018 Dec;13(6):500-508
pubmed: 30607148
Talanta. 2009 Jul 15;79(2):344-51
pubmed: 19559889
Phytomedicine. 2016 Oct 15;23(11):1082-9
pubmed: 26656228