Endometrial preparation for frozen-thawed embryo transfer in an artificial cycle: transdermal versus vaginal estrogen.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 01 2020
22 01 2020
Historique:
received:
29
09
2019
accepted:
19
12
2019
entrez:
24
1
2020
pubmed:
24
1
2020
medline:
20
11
2020
Statut:
epublish
Résumé
The objective was to compare the endometrial thickness (ET) in a frozen embryo transfer (FET) cycle between transdermal and vaginal estrogen. Our secondary objectives were to compare the patient satisfaction and the pregnancy outcomes. Prospective monocentric cohort study between 01/2017 and 12/2017 at a single institution. Choice of administration was left to the patient. 119 cycles had transdermal estrogen (T-group) and 199 had vaginal estrogen (V-group). The ET at 10 ± 1 days of treatment was significantly higher in the T-group compared to the V-group (9.9 vs 9.3 mm, p = 0.03). In the T-group, the mean duration of treatment was shorter (13.6 vs 15.5 days, p < 0.001). The rate of cycle cancelation was comparable between the two groups (12.6% vs 8.5%, p = 0.24). Serum estradiol levels were significantly lower (268 vs 1332 pg/ml, p < 0.001), and serum LH levels were significantly higher (12.1 ± 16.5 vs 5 ± 7.5 mIU/ml, p < 0.001) in the T-group. Patient satisfaction was higher in the T-group (p = 0.04) and 85.7% (36/42) of women who had received both treatments preferred the transdermal over the vaginal route. Live birth rates were comparable between the two groups (18% vs 19%, p = 0.1). Transdermal estrogen in artificial FET cycles was associated with higher ET, shorter treatment duration and better tolerance.
Identifiants
pubmed: 31969591
doi: 10.1038/s41598-020-57730-3
pii: 10.1038/s41598-020-57730-3
pmc: PMC6976623
doi:
Substances chimiques
Estrogens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
985Références
CDC. American Society for Reproductive Medicine; Society for Assisted Reproductive Technology. 2016 assisted reproductive technology national summary report. Atlanta, GA: US Department of Health and Human Services, CDC. (2018).
McLernon, D. J. et al. Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomised trials. BMJ 341, c6945 (2010).
doi: 10.1136/bmj.c6945
Agence de la Biomédecine. Activité d’Assistance Médicale à la Procréation - Rapport de l’Agence de la biomédecine. (2015).
Shapiro, B. S. et al. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders. Fertility and Sterility 96, 516–518 (2011).
doi: 10.1016/j.fertnstert.2011.02.059
Yarali, H., Polat, M., Mumusoglu, S., Yarali, I. & Bozdag, G. Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis. J. Assist. Reprod. Genet. 33, 1287–1304 (2016).
doi: 10.1007/s10815-016-0787-0
Mackens, S. et al. Frozen embryo transfer: a review on the optimal endometrial preparation and timing. Hum. Reprod. 32, 2234–2242 (2017).
doi: 10.1093/humrep/dex285
Wright, K. P. et al. Artificial versus stimulated cycles for endometrial preparation prior to frozen-thawed embryo transfer. Reprod. Biomed. Online 13, 321–325 (2006).
doi: 10.1016/S1472-6483(10)61434-4
Groenewoud, E. R. et al. A randomized controlled, non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer. Hum. Reprod. 31, 1483–1492 (2016).
doi: 10.1093/humrep/dew120
Ziegler, W. F. & Russell, J. B. High success with gestational carriers and oocyte donors using synchronized cycles. J. Assist. Reprod. Genet. 12, 297–300 (1995).
doi: 10.1007/BF02213707
Abu-Musa, A., Hannoun, A., Khalil, A., Masaad, Z. & Karam, K. Artificial endometrial preparation for oocyte donation using synthetic estrogen and progestogen. Clin Exp Obstet Gynecol 25, 83–85 (1998).
pubmed: 9856304
Devroey, P. & Pados, G. Preparation of endometrium for egg donation. Hum. Reprod. Update 4, 856–861 (1998).
doi: 10.1093/humupd/4.6.856
Paulson, R. J. Hormonal induction of endometrial receptivity. Fertil. Steril. 96, 530–535 (2011).
doi: 10.1016/j.fertnstert.2011.07.1097
Li, T. C. et al. Endometrial responses in artificial cycles: a prospective study comparing four different oestrogen dosages. Br J Obstet Gynaecol 99, 751–756 (1992).
doi: 10.1111/j.1471-0528.1992.tb13878.x
Krasnow, J. S. et al. Comparison of transdermal versus oral estradiol on endometrial receptivity. Fertil. Steril. 65, 332–336 (1996).
doi: 10.1016/S0015-0282(16)58094-7
Weissman, A., Leong, M., Sauer, M. V. & Shoham, Z. Characterizing the practice of oocyte donation: a web-based international survey. Reprod. Biomed. Online 28, 443–450 (2014).
doi: 10.1016/j.rbmo.2013.12.004
Kuhl, H. Pharmacokinetics of oestrogens and progestogens. Maturitas 12, 171–197 (1990).
doi: 10.1016/0378-5122(90)90003-O
Jiménez, P. T., Schon, S. B., Odem, R. R., Ratts, V. S. & Jungheim, E. S. A retrospective cross-sectional study: fresh cycle endometrial thickness is a sensitive predictor of inadequate endometrial thickness in frozen embryo transfer cycles. in Reproductive biology and endocrinology: RB&E, https://doi.org/10.1186/1477-7827-11-35 (2013).
El-Toukhy, T. et al. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil. Steril. 89, 832–839 (2008).
doi: 10.1016/j.fertnstert.2007.04.031
Bu, Z., Wang, K., Dai, W. & Sun, Y. Endometrial thickness significantly affects clinical pregnancy and live birth rates in frozen-thawed embryo transfer cycles. Gynecol. Endocrinol. 32, 524–528 (2016).
doi: 10.3109/09513590.2015.1136616
Liu, K. E., Hartman, M., Hartman, A., Luo, Z.-C. & Mahutte, N. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Hum. Reprod. 33, 1883–1888 (2018).
doi: 10.1093/humrep/dey281
Ferrer-Molina, P. et al. Oral versus transdermal oestrogen delivery for endometrial preparation before embryo transfer: a prospective, comparative, randomized clinical trial. Reprod. Biomed. Online 37, 693–702 (2018).
doi: 10.1016/j.rbmo.2018.09.003
Davar, R., Janati, S., Mohseni, F., Khabazkhoob, M. & Asgari, S. A Comparison of the Effects of Transdermal Estradiol and Estradiol Valerate on Endometrial Receptivity in Frozen-thawed Embryo Transfer Cycles: A Randomized Clinical Trial. J Reprod Infertil 17, 97–103 (2016).
pubmed: 27141464
pmcid: 4842240
Kahraman, S., Çetinkaya, C. P., Sahin, Y. & Oner, G. Transdermal versus oral estrogen: clinical outcomes in patients undergoing frozen-thawed single blastocyst transfer cycles without GnRHa suppression, a prospective randomized clinical trial. J. Assist. Reprod. Genet. 36, 453–459 (2019).
doi: 10.1007/s10815-018-1380-5
Tourgeman, D. E., Gentzchein, E., Stanczyk, F. Z. & Paulson, R. J. Serum and tissue hormone levels of vaginally and orally administered estradiol. Am. J. Obstet. Gynecol. 180, 1480–1483 (1999).
doi: 10.1016/S0002-9378(99)70042-6
Bilsel, A. S., Onaran, N., Moini, H. & Emerk, K. Long-term effect of 17beta-estradiol and thrombin on tissue factor pathway inhibitor release from HUVEC. Thromb. Res. 99, 173–178 (2000).
doi: 10.1016/S0049-3848(00)00228-0
Richardson, M. A. et al. 17beta-estradiol, but not raloxifene, decreases thrombomodulin in the antithrombotic protein C pathway. Endocrinology 141, 3908–3911 (2000).
doi: 10.1210/endo.141.10.7798
Farhi, J. et al. High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation. Reprod. Biomed. Online 21, 331–337 (2010).
doi: 10.1016/j.rbmo.2010.04.022
Imudia, A. N. et al. Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization. Fertil. Steril. 97, 1374–1379 (2012).
doi: 10.1016/j.fertnstert.2012.03.028
Hu, X.-L. et al. High maternal serum estradiol environment in the first trimester is associated with the increased risk of small-for-gestational-age birth. J. Clin. Endocrinol. Metab. 99, 2217–2224 (2014).
doi: 10.1210/jc.2013-3362
Treeck, O., Diepolder, E., Skrzypczak, M., Schüler-Toprak, S. & Ortmann, O. Knockdown of estrogen receptor β increases proliferation and affects the transcriptome of endometrial adenocarcinoma cells. BMC Cancer 19, 745 (2019).
doi: 10.1186/s12885-019-5928-2
Bouskine, A. et al. Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A. Endocrinology 149, 565–573 (2008).
doi: 10.1210/en.2007-1318
Hartman, J. et al. Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. Cancer Res. 66, 11207–11213 (2006).
doi: 10.1158/0008-5472.CAN-06-0017
Dal Prato, L. et al. Endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with gonadotropin-releasing hormone agonist. Fertil. Steril. 77, 956–960 (2002).
doi: 10.1016/S0015-0282(02)02960-6
Glujovsky, D. et al. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev CD006359, https://doi.org/10.1002/14651858.CD006359.pub2 (2010)
Agence de la Biomédecine. Evaluation des résultats des centres d’assistance médicale à la procréation pratiquant la fécondation in vitro en France. Agence de le Biomedecine. Rapport national des résultats. https://www.agence-biomedecine.fr/IMG/pdf/nationalcompletfiv2014.pdf (2014).
De Geyter, C. et al. ART in Europe, 2014: results generated from European registries by ESHRE: The European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE). Hum. Reprod. 33, 1586–1601 (2018).
doi: 10.1093/humrep/dey242
Madero, S., Rodriguez, A., Vassena, R. & Vernaeve, V. Endometrial preparation: effect of estrogen dose and administration route on reproductive outcomes in oocyte donation cycles with fresh embryo transfer. Hum. Reprod. 31, 1755–1764 (2016).
doi: 10.1093/humrep/dew099
Gardner, D., Lane, M., Stevens, J., Schlenker, T. & Schoolcraft, W. B. Blastocyst score affects implantation and pregnancy outcome: Towards a single blastocyst transfer. Fertility and sterility 73, 1155–8 (2000).
doi: 10.1016/S0015-0282(00)00518-5