A randomized trial of nurse-administered behavioral interventions to manage anticipatory nausea and vomiting in chemotherapy.
classical conditioning/music therapy/relaxation therapy
nausea/vomiting/anticipatory nausea
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
12
09
2019
revised:
06
01
2020
accepted:
07
01
2020
pubmed:
21
1
2020
medline:
24
4
2021
entrez:
21
1
2020
Statut:
ppublish
Résumé
Chemotherapy side effects diminish quality of life and can lead to treatment delay. Nausea and vomiting can occur prior to chemotherapy because of classical conditioning. We studied the effects of 20-minute behavioral interventions, administered by oncology nurses, of higher intensity (mindfulness relaxation-MR) or lower intensity (relaxing music-RM), on anticipatory nausea and vomiting (ANV). Patients undergoing chemotherapy for solid tumors were randomized to MR (N = 160), RM (N = 159), or standard care SC (N = 155). Subjects were mostly female (91.8%) and white (86.1%) with breast cancer (85%). Most patients had early stage disease (Stage I: 26%; II: 52.9%; III: 19%; IV: 0.1%). Anticipatory nausea and vomiting were assessed at the midpoint and end of the chemotherapy course using the Morrow Assessment of Nausea and Emesis (MANE). Compared to SC, there was reduced anticipatory nausea at the midpoint of chemotherapy in those receiving MR (OR 0.44, 95% CI 0.20-0.93) and RM (OR 0.40, 95% CI 0.20-0.93), controlling for age, sex, cancer stage, and emetogenic level of chemotherapy. There was no difference between treatment groups in anticipatory nausea at the end of chemotherapy or in anticipatory vomiting and postchemotherapy nausea and vomiting at either time point. A brief nurse-delivered behavioral intervention can reduce midpoint ANV associated with chemotherapy.
Identifiants
pubmed: 31957269
doi: 10.1002/cam4.2863
pmc: PMC7050098
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1733-1740Subventions
Organisme : NCI NIH HHS
ID : U10 CA045809
Pays : United States
Informations de copyright
© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Références
J Altern Complement Med. 2012 May;18(5):473-9
pubmed: 22525009
Br J Cancer. 1999 Apr;80(1-2):262-8
pubmed: 10390006
Gen Hosp Psychiatry. 1994 Sep;16(5):340-7
pubmed: 7995505
J Consult Clin Psychol. 1987 Feb;55(1):42-8
pubmed: 3553262
Br J Cancer. 2006 Apr 10;94(7):1011-5
pubmed: 16552437
Cancer Sci. 2010 Dec;101(12):2596-600
pubmed: 20946120
J Behav Med. 1981 Mar;4(1):65-78
pubmed: 7026794
J Adv Nurs. 2009 Jul;65(7):1356-64
pubmed: 19456998
Eur J Cancer Care (Engl). 2007 Nov;16(6):462-74
pubmed: 17944760
World J Gastroenterol. 2007 Jul 7;13(25):3430-7
pubmed: 17659689
PLoS One. 2017 Oct 10;12(10):e0184360
pubmed: 29016607
Support Care Cancer. 2015 Jan;23(1):283-91
pubmed: 25112561
Clin Adv Hematol Oncol. 2013 Feb;11(2 Suppl 1):1-18; quiz 2 p following 18
pubmed: 23598819
J Consult Clin Psychol. 1982 Dec;50(6):1018-29
pubmed: 7174969
J Behav Med. 1985 Jun;8(2):163-90
pubmed: 3897551
Health Psychol. 1992;11(4):250-6
pubmed: 1396493
Support Care Cancer. 1998 May;6(3):221-7
pubmed: 9629873
J Consult Clin Psychol. 1985 Aug;53(4):447-54
pubmed: 4031199
Psychooncology. 2005 Aug;14(8):607-17
pubmed: 15651053
Oncology (Williston Park). 1993 Dec;7(12):83-9; discussion 93-4, 97
pubmed: 8292509
Cancer. 1984 May 15;53(10 Suppl):2267-80
pubmed: 6704914
J Adv Pract Oncol. 2015 May-Jun;6(3):225-9
pubmed: 26557409
Cancer Med. 2020 Mar;9(5):1733-1740
pubmed: 31957269
Eur J Pharmacol. 2014 Jan 5;722:172-9
pubmed: 24157982
Cochrane Database Syst Rev. 2017 Jan 03;1:CD010802
pubmed: 28045199
Brain Cogn. 2016 Oct;108:32-41
pubmed: 27429096
Cancer Nurs. 1990 Oct;13(5):308-15
pubmed: 2245418
J Pain Symptom Manage. 2016 Jun;51(6):987-93
pubmed: 26891606
Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8865-70
pubmed: 19451642
Expert Opin Pharmacother. 2013 Apr;14(6):757-66
pubmed: 23496347
J Pain Symptom Manage. 1992 Jul;7(5):287-301
pubmed: 1624814
J Clin Nurs. 2011 Apr;20(7-8):988-99
pubmed: 21385249