Acellular Biologic Nipple-Areolar Complex Graft:

Animals Biological Products Breast Neoplasms Female Macaca mulatta Mammaplasty Mastectomy Mice Nipples / transplantation Pilot Projects Proteomics Plastic Surgery Procedures
acellular biological matrix breast cancer breast reconstruction nipple reconstruction nipple-areolar complex

Journal

Tissue engineering. Part A
ISSN: 1937-335X
Titre abrégé: Tissue Eng Part A
Pays: United States
ID NLM: 101466659

Informations de publication

Date de publication:
08 2020
Historique:
pubmed: 18 1 2020
medline: 24 9 2021
entrez: 18 1 2020
Statut: ppublish

Résumé

There are more than 3 million breast cancer survivors living in the United States of which a significant number have undergone mastectomy followed by breast and nipple-areolar complex (NAC) reconstruction. Current strategies for NAC reconstruction are dependent on nonliving or nonpermanent techniques, including tattooing, nipple prosthetics, or surgical nipple-like structures. Described herein is a tissue engineering approach demonstrating the feasibility of an allogeneic acellular graft for nipple reconstruction. Nonhuman primate (NHP)-derived NAC tissues were decellularized and their extracellular matrix components analyzed by both proteomic and histological analyses. Decellularized NHP nipple tissue showed the removal of intact cells and greatly diminished profiles for intracellular proteins, as compared with intact NHP nipple tissue. We further evaluated the biocompatibility of decellularized grafts and their potential to support host-mediated neovascularization against commercially available acellular dermal grafts by performing

Identifiants

DOI: 10.1089/ten.TEA.2019.0222 PMID: 31950890 PMC: PMC7462026
pubmed: 31950890
doi: 10.1089/ten.TEA.2019.0222
pmc: PMC7462026
doi:

Substances chimiques

Biological Products 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

872-885

Subventions

Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States

Références

Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Biomaterials. 2013 Jan;34(3):669-76
pubmed: 23102991
Mol Cell Proteomics. 2015 Apr;14(4):961-73
pubmed: 25660013
Acta Histochem Cytochem. 2011 Oct 26;44(5):191-9
pubmed: 22096259
World J Plast Surg. 2017 Jan;6(1):68-73
pubmed: 28289616
Cells Tissues Organs. 2017;203(3):183-193
pubmed: 28125805
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
Stem Cells. 2017 Feb;35(2):532-544
pubmed: 27733015
Eplasty. 2018 Mar 19;18:e15
pubmed: 29623151
Adv Drug Deliv Rev. 2003 Nov 28;55(12):1531-46
pubmed: 14623400
J Plast Surg Hand Surg. 2017 Oct;51(5):287-295
pubmed: 27885878
Gland Surg. 2017 Feb;6(1):4-13
pubmed: 28210547
Aesthetic Plast Surg. 2006 Jul-Aug;30(4):399-402
pubmed: 16786203
Plast Reconstr Surg Glob Open. 2016 Aug 09;4(8):e832
pubmed: 27622100
Stem Cells. 2017 Oct;35(10):2198-2207
pubmed: 28801931
Annu Rev Physiol. 2018 Feb 10;80:353-387
pubmed: 29433414
J Biomech. 2014 Jun 27;47(9):2070-9
pubmed: 24702863
J Vis Exp. 2013 Dec 15;(82):e50825
pubmed: 24378384
Breast Cancer Res Treat. 2012 Apr;132(3):1177-84
pubmed: 22350788
Ann Surg Oncol. 2018 Oct;25(10):2909-2916
pubmed: 29968023
Ann Plast Surg. 2012 Oct;69(4):389-93
pubmed: 22868326
Tissue Eng Part A. 2014 May;20(9-10):1426-43
pubmed: 24378017
Plast Reconstr Surg. 2002 Sep 1;110(3):780-6
pubmed: 12172139
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Int J Adv Eng Sci Appl Math. 2013 Dec 1;4(4):228-240
pubmed: 24944461
J Plast Reconstr Aesthet Surg. 2011 Mar;64(3):360-3
pubmed: 20570584
Breast Cancer Res Treat. 2018 Jun;169(2):381-390
pubmed: 29392581
Arch Plast Surg. 2014 Mar;41(2):158-62
pubmed: 24665425
Indian J Plast Surg. 2011 Jan;44(1):76-80
pubmed: 21713165
J Biomed Mater Res A. 2018 Sep;106(9):2481-2493
pubmed: 29693792
J Tissue Eng Regen Med. 2018 Feb;12(2):e786-e806
pubmed: 27943597
Plast Reconstr Surg. 2020 Jan;145(1):38-42
pubmed: 31881601
Tissue Eng Part B Rev. 2019 Apr;25(2):126-134
pubmed: 30379123
Plast Reconstr Surg. 2002 Aug;110(2):457-63; discussion 464-5
pubmed: 12142660
J Tissue Eng. 2014 Dec 20;5:2041731414557112
pubmed: 25610589
J Plast Reconstr Aesthet Surg. 2017 Feb;70(2):209-214
pubmed: 27988150
J Psychosoc Oncol. 2011;29(6):664-76
pubmed: 22035539
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W597-603
pubmed: 22661580
Plast Reconstr Surg. 2006 Nov;118(6):1303-12
pubmed: 17051099
J Invest Dermatol. 2011 Apr;131(4):892-9
pubmed: 21228814
Curr Biol. 2013 Nov 18;23(22):2233-2244
pubmed: 24210613

Auteurs

Nicholas C Pashos (NC)

Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Bioinnovation PhD Program, Tulane University, School of Science and Engineering, New Orleans, Louisiana, USA.
BioAesthetics Corporation, Research Triangle Park, North Carolina, USA.
Tulane National Primate Research Center, Covington, Louisiana, USA.

David M Graham (DM)

BioAesthetics Corporation, Research Triangle Park, North Carolina, USA.

Brian J Burkett (BJ)

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Ben O'Donnell (B)

Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Bioinnovation PhD Program, Tulane University, School of Science and Engineering, New Orleans, Louisiana, USA.

Rachel A Sabol (RA)

Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Joshua Helm (J)

Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Elizabeth C Martin (EC)

Department of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, Louisiana, USA.

Annie C Bowles (AC)

Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.

William M Heim (WM)

BioAesthetics Corporation, Research Triangle Park, North Carolina, USA.

Vince C Caronna (VC)

BioAesthetics Corporation, Research Triangle Park, North Carolina, USA.

Kristin S Miller (KS)

Department of Biomedical Engineering, Tulane University, School of Science and Engineering, New Orleans, Louisiana, USA.

Brooke Grasperge (B)

Tulane National Primate Research Center, Covington, Louisiana, USA.

Scott Sullivan (S)

Center for Restorative Breast Surgery, New Orleans, Louisiana, USA.

Abigail E Chaffin (AE)

Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Bruce A Bunnell (BA)

Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Tulane National Primate Research Center, Covington, Louisiana, USA.
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Mélanges complexes › Produits biologiques › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Procédures de chirurgie opératoire › Procédures de chirurgie reconstructive › Mammoplastie › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Procédures de chirurgie opératoire › Mastectomie › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Régions du corps › Région mammaire › Mamelons › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Acellular Biologic Nipple-Areolar Complex Graft:
Recherchemedicale.com › Procédures de chirurgie opératoire › Procédures de chirurgie reconstructive › Acellular Biologic Nipple-Areolar Complex Graft: