The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer.
Cancer
esophagogastric junction
neoadjuvant chemotherapy
peritoneal lavage
Journal
Journal of cytology
ISSN: 0970-9371
Titre abrégé: J Cytol
Pays: India
ID NLM: 8915204
Informations de publication
Date de publication:
Historique:
received:
10
10
2018
revised:
01
03
2019
accepted:
24
10
2019
entrez:
17
1
2020
pubmed:
17
1
2020
medline:
17
1
2020
Statut:
ppublish
Résumé
The utility of peritoneal washing cytology in patients with gastroesophageal junction cancer has not been thoroughly evaluated. The study aimed to determine the incidence of free peritoneal tumor cells by peritoneal washing cytology before and after neoadjuvant chemotherapy using conventional cytopathological methods and immunohistochemical staining for the analysis of peritoneal washings. A prospective study conducted at a single tertiary referral hospital. Patients with gastroesophageal junction cancer and without suspicion of intra- or extraabdominal metastases before the staging laparoscopy were prospectively and consecutively enrolled. Peritoneal washing cytology was performed at staging laparoscopy (primary cytology) and after neoadjuvant chemotherapy during robot-assisted or open resection (secondary cytology). Peritoneal fluid samples were analyzed by conventional cytology and an immunohistochemical panel. Overall, 81 patients met the primary inclusion criteria. During primary cytology, positive cytology without overt metastases (C1M0) was detected in three patients (3.8%) while five patients (6.3%) had overt intra-abdominal metastases but negative cytology (C0M1). None of the patients with C1M0 underwent surgery due to extra-abdominal ( The incidence of C1M0 was 3.8% and 0% before and after neoadjuvant chemotherapy, respectively in patients with gastroesophageal junction cancer. Free peritoneal tumor cells were not identified in several patients with intra-abdominal metastases suggesting that peritoneal washing cytology with conventional cytology and immunohistochemical staining lack sensitivity.
Identifiants
pubmed: 31942097
doi: 10.4103/JOC.JOC_164_18
pii: JCytol-37-40
pmc: PMC6947737
doi:
Types de publication
Journal Article
Langues
eng
Pagination
40-45Informations de copyright
Copyright: © 2019 Journal of Cytology.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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