Linaburiosides A-D, acylated iridoid glucosides from Linaria buriatica.
A549 Cells
Acylation
Anti-Inflammatory Agents
/ chemistry
Glucosides
/ chemistry
Humans
Interleukin-1beta
/ antagonists & inhibitors
Iridoids
/ chemistry
Linaria
/ chemistry
Lipopolysaccharides
/ antagonists & inhibitors
MCF-7 Cells
Microglia
/ drug effects
Molecular Conformation
Phytochemicals
/ chemistry
Tumor Cells, Cultured
Anti-inflammatory activity
Iridoid glucoside
Linaria buriatica
Mongolian traditional herbal medicine
Plantaginaceae
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
28
08
2019
revised:
21
12
2019
accepted:
21
12
2019
pubmed:
14
1
2020
medline:
17
3
2020
entrez:
14
1
2020
Statut:
ppublish
Résumé
Four previously undescribed acylated iridoid glucosides, linaburiosides A‒D, one undescribed iridoid, 7-deoxyiridolactonic acid, and one known acylated iridoid glucoside, iridolinarin C, were isolated from the aerial parts of a Mongolian traditional herbal medicine, Linaria buriatica. Linaburiosides A‒D had an acyl moiety corresponding to 7-deoxyiridolactonic acid. Detailed spectroscopic analyses of linaburiosides A‒D and 7-deoxyiridolactonic acid led to the assignment of their structures. The absolute configuration of 7-deoxyiridolactonic acid was elucidated by application of the PGME method; those of linaburiosides A‒D were assigned on the basis of chemical conversions, as well as application of the modified Mosher's method. The absolute configuration of iridolinarin C was also elucidated in this study. Anti-inflammatory and antiproliferative activities of isolated compounds and their derivatives were evaluated.
Identifiants
pubmed: 31927201
pii: S0031-9422(19)30838-6
doi: 10.1016/j.phytochem.2019.112247
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Glucosides
0
Interleukin-1beta
0
Iridoids
0
Lipopolysaccharides
0
Phytochemicals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112247Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.