Safety and Efficacy of Steroid Pulse Therapy for Acute Loss of FEV


Journal

Transplantation proceedings
ISSN: 1873-2623
Titre abrégé: Transplant Proc
Pays: United States
ID NLM: 0243532

Informations de publication

Date de publication:
Historique:
received: 21 05 2019
accepted: 06 10 2019
pubmed: 14 1 2020
medline: 24 7 2020
entrez: 14 1 2020
Statut: ppublish

Résumé

The standard treatment of acute cellular rejection after lung transplantation (LTx) is a high-dose steroid pulse therapy. In our center, this therapy is also the standard of care for LTx recipients with acute loss of forced expiratory volume in 1 second (FEV From 2015 to 2018, 33 consecutive patients (17 male patients, mean age ± SD, 50.5 ± 12.5 years) were included. All patients underwent routine examinations to exclude acute cellular rejection and other specific causes. FEV The mean decrease ± SD from baseline in FEV Only a minority of patients after LTx with loss of FEV

Sections du résumé

BACKGROUND BACKGROUND
The standard treatment of acute cellular rejection after lung transplantation (LTx) is a high-dose steroid pulse therapy. In our center, this therapy is also the standard of care for LTx recipients with acute loss of forced expiratory volume in 1 second (FEV
METHODS METHODS
From 2015 to 2018, 33 consecutive patients (17 male patients, mean age ± SD, 50.5 ± 12.5 years) were included. All patients underwent routine examinations to exclude acute cellular rejection and other specific causes. FEV
RESULTS RESULTS
The mean decrease ± SD from baseline in FEV
CONCLUSIONS CONCLUSIONS
Only a minority of patients after LTx with loss of FEV

Identifiants

pubmed: 31926742
pii: S0041-1345(19)30858-9
doi: 10.1016/j.transproceed.2019.10.013
pii:
doi:

Substances chimiques

Glucocorticoids 0
Prednisone VB0R961HZT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

309-314

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Dieter Munker (D)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany. Electronic address: dieter.munker@med.uni-muenchen.de.

Paola Arnold (P)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Tobias Veit (T)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Gabriela Leuschner (G)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Felix Ceelen (F)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Michaela Barnikel (M)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Magdalena Schmitzer (M)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Jürgen Barton (J)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Torben Sonneck (T)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Katrin Milger (K)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Sandhya Matthes (S)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Sanziana Schiopu (S)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Teresa Kauke (T)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; Department of Thoracic Surgery, Ludwig Maximilian University of Munich, Munich, Germany.

Thomas Weig (T)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; Department of Anesthesiology, Ludwig Maximilian University of Munich, Munich, Germany.

Nikolaus Kneidinger (N)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Jürgen Behr (J)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; German Center for Lung Research, Giessen, Germany.

Claus Neurohr (C)

Department of Internal Medicine V-Pulmonology, Ludwig Maximilian University of Munich, Munich, Germany; Department of Pneumology and Respiratory medicine, Hospital Schillerhoehe, University of Tuebingen, Gerlingen, Germany.

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Classifications MeSH