Zinc alleviates maneb-induced kidney injury in adult mice through modulation of oxidative stress, genotoxicity, and histopathological changes.


Journal

Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 25 06 2019
accepted: 25 11 2019
pubmed: 4 1 2020
medline: 6 5 2020
entrez: 4 1 2020
Statut: ppublish

Résumé

Zinc is one of the important essential trace minerals to human health due to its antioxidant properties. The present study was conducted to elucidate its potential protective role against maneb-induced nephrotoxicity. For this purpose, animals were randomly divided into four groups of six each. Mice of group I (negative controls) have received daily 0.5 ml of distilled water, a solvent of maneb. Mice of group II (MB) have received 30 mg/kg bw of maneb daily by intraperitoneal way. Mice of group III (MB + Zn) have received the same dose of maneb as group II, along with ZnSO

Identifiants

pubmed: 31897980
doi: 10.1007/s11356-019-07175-7
pii: 10.1007/s11356-019-07175-7
doi:

Substances chimiques

Antioxidants 0
Glutathione GAN16C9B8O
Glutathione Peroxidase EC 1.11.1.9
Maneb 12427-38-2
Superoxide Dismutase EC 1.15.1.1
Zinc J41CSQ7QDS

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8091-8102

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Auteurs

Mediha Sefi (M)

Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sciences Faculty of Sfax, Sfax, Tunisia. essafimediha@gmail.com.
Ecology, Biology and physiology laboratory of aquatic organisms, Department of Biological Sciences, Sciences Faculty of Tunis, University Tunis El Manar, 2092, Tunis, Tunisia. essafimediha@gmail.com.

Mariem Chaâbane (M)

Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sciences Faculty of Sfax, Sfax, Tunisia.

Awatef Elwej (A)

Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sciences Faculty of Sfax, Sfax, Tunisia.

Safa Bejaoui (S)

Ecology, Biology and physiology laboratory of aquatic organisms, Department of Biological Sciences, Sciences Faculty of Tunis, University Tunis El Manar, 2092, Tunis, Tunisia.

Rim Marrekchi (R)

Biochemistry Laboratory, Department of Biochemistry, CHU Hedi Chaker, University of Sfax, 3029, Sfax, Tunisia.

Kamel Jamoussi (K)

Biochemistry Laboratory, Department of Biochemistry, CHU Hedi Chaker, University of Sfax, 3029, Sfax, Tunisia.

Naourez Gouiaa (N)

Histopathology Laboratory, Department of Anatomo-pathology, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia.

Tahia Boudawara Sellami (T)

Histopathology Laboratory, Department of Anatomo-pathology, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia.

M'hamed El Cafsi (M)

Ecology, Biology and physiology laboratory of aquatic organisms, Department of Biological Sciences, Sciences Faculty of Tunis, University Tunis El Manar, 2092, Tunis, Tunisia.

Najiba Zeghal (N)

Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sciences Faculty of Sfax, Sfax, Tunisia.

Nejla Soudani (N)

Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sciences Faculty of Sfax, Sfax, Tunisia.
Ecology, Biology and physiology laboratory of aquatic organisms, Department of Biological Sciences, Sciences Faculty of Tunis, University Tunis El Manar, 2092, Tunis, Tunisia.

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Classifications MeSH