Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
13 02 2020
13 02 2020
Historique:
pubmed:
3
1
2020
medline:
4
8
2020
entrez:
3
1
2020
Statut:
ppublish
Résumé
Optimization of compound lipophilicity is a key aspect of drug discovery. The aim of this work was to compare the lipophilicity modulations induced by 16 distinct known and novel fluoroalkyl motifs on three parent models. Fifty fluorinated compounds, with 28 novel experimental aliphatic log
Identifiants
pubmed: 31894985
doi: 10.1021/acs.jmedchem.9b01172
doi:
Substances chimiques
Hydrocarbons, Fluorinated
0
Pentanols
0
1-Butanol
8PJ61P6TS3
n-pentanol
M9L931X26Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM