Expression of vascular endothelial growth factor A in liver tissues of infants with biliary atresia.
biliary atresia
cytokeratin
growth factor
Journal
Clinical and experimental hepatology
ISSN: 2392-1099
Titre abrégé: Clin Exp Hepatol
Pays: Poland
ID NLM: 101703431
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
22
07
2019
accepted:
01
08
2019
entrez:
2
1
2020
pubmed:
2
1
2020
medline:
2
1
2020
Statut:
ppublish
Résumé
Assessment of hepatic expression of vascular endothelial growth factor A (VEGF-A) in liver tissues of infants with biliary atresia (BA). This retrospective study included 35 infants with BA (BA group), and 38 infants with cholestasis due to causes other than BA (non-BA group). All patients had undergone full history taking, through clinical examination, routine investigations and immunostaining of liver tissue for VEGF-A and cytokeratin 7 (CK7). The diagnosis of BA was confirmed by intraoperative cholangiography. In the non-BA group, other specific laboratory tests according to the expected etiology were done. Most of the BA group showed positive VEGF-A expression with variable degrees in both bile ducts (BDs; 80%), and arterial walls (AWs; 77.2%), while most of the non-BA group showed negative staining of VEGF in both BDs and AWs (89.5% and 86.8% respectively) ( VEGF-A expression in the portal structures in liver tissues in both BDs and AWs had very good accuracy in discriminating between BA and non-BA patients.
Identifiants
pubmed: 31893243
doi: 10.5114/ceh.2019.89476
pii: 38476
pmc: PMC6935852
doi:
Types de publication
Journal Article
Langues
eng
Pagination
308-316Informations de copyright
Copyright: © 2019 Clinical and Experimental Hepatology.
Déclaration de conflit d'intérêts
The authors report no conflict of interest.
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