In Utero Exposure to Glucocorticoids and Pubertal Timing in Sons and Daughters.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 12 2019
30 12 2019
Historique:
received:
12
08
2019
accepted:
17
12
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
12
11
2020
Statut:
epublish
Résumé
Early pubertal timing has been associated with adult diseases, and identifying preventable causes is of importance. In utero exposure to exogenous glucocorticoids, has been associated with changes in the reproductive hormonal axes in the children, which may influence pubertal timing. Exogenous glucocorticoids can be indicated for diseases such as asthma, allergy, skin diseases, as well as muscle and joint diseases. The aim was to explore the association between in utero exposure to glucocorticoids and pubertal timing in the children. This population-based study was conducted in the Puberty Cohort including 15,819 children, which is a sub-cohort of the Danish National Birth Cohort. Information on maternal glucocorticoid treatment was collected through interviews during pregnancy. Information on pubertal timing was obtained by questionnaires every 6 months throughout puberty, including Tanner Stages, axillary hair, acne, voice break, first ejaculation and menarche. The potential impact of confounding by indication was explored by stratifying on indication and treatment status. Overall, 6.8% of the children were exposed to glucocorticoids in utero. Exposure to glucocorticoids in utero was not associated with earlier puberty for neither boys nor girls with combined estimates of 0.4 months (95% CI: -1.5; 2.2) and -0.7 months (95% CI: -2.5; 1.2).
Identifiants
pubmed: 31889153
doi: 10.1038/s41598-019-56917-7
pii: 10.1038/s41598-019-56917-7
pmc: PMC6937234
doi:
Substances chimiques
Glucocorticoids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20374Références
Nat Rev Endocrinol. 2014 Jul;10(7):391-402
pubmed: 24863382
Curr Opin Endocrinol Diabetes Obes. 2018 Feb;25(1):49-54
pubmed: 29135489
Reproduction. 2005 Jun;129(6):675-83
pubmed: 15923383
J Clin Endocrinol Metab. 2016 Jul;101(7):2667-74
pubmed: 27014950
Arch Dis Child. 1969 Jun;44(235):291-303
pubmed: 5785179
Scand J Public Health. 2001 Dec;29(4):300-7
pubmed: 11775787
Endocr Rev. 2009 Dec;30(7):753-89
pubmed: 19837868
Br J Clin Pharmacol. 2015 Sep;80(3):372-80
pubmed: 25808113
BMC Med Res Methodol. 2008 Oct 30;8:70
pubmed: 18973665
Pediatrics. 2008 Feb;121 Suppl 3:S218-30
pubmed: 18245514
Endocr Rev. 2013 Dec;34(6):885-916
pubmed: 23970762
Epidemiology. 2001 Sep;12(5):497-501
pubmed: 11505166
Dev Rev. 2007 Jun;27(2):151-171
pubmed: 20740062
Asthma Res Pract. 2018 Dec 27;4:11
pubmed: 30607253
Stress. 2017 Sep;20(5):476-494
pubmed: 28859530
Cochrane Database Syst Rev. 2016 Apr 26;4:CD011993
pubmed: 27115215
Endocrinology. 2000 Jul;141(7):2422-8
pubmed: 10875242
J Pediatr Endocrinol Metab. 2018 Jul 26;31(7):763-772
pubmed: 29953412
N Engl J Med. 2008 Jul 3;359(1):61-73
pubmed: 18596274
Epidemiology. 2004 Sep;15(5):615-25
pubmed: 15308962
Nat Clin Pract Endocrinol Metab. 2007 Jun;3(6):479-88
pubmed: 17515892
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
Am J Epidemiol. 2019 Jan 1;188(1):47-56
pubmed: 30239589
Annu Rev Public Health. 2016;37:33-46
pubmed: 26789387
Am J Respir Crit Care Med. 2012 Mar 1;185(5):557-63
pubmed: 22198975
Arch Dis Child. 1970 Feb;45(239):13-23
pubmed: 5440182
J Investig Allergol Clin Immunol. 2012;22(1):1-12
pubmed: 22448448
Endocrinology. 2018 Jan 1;159(1):69-82
pubmed: 29136116
Pediatrics. 2008 Feb;121 Suppl 3:S172-91
pubmed: 18245511
Mol Cell Endocrinol. 2011 Mar 15;335(1):2-13
pubmed: 20398732
Mol Cell Endocrinol. 2006 Jul 25;254-255:8-12
pubmed: 16757103
Clin Pharmacokinet. 1979 Mar-Apr;4(2):111-28
pubmed: 378499
Eur Arch Otorhinolaryngol. 2018 Feb;275(2):325-333
pubmed: 29164323
Cochrane Database Syst Rev. 2013 Feb 28;(2):CD009611
pubmed: 23450606
Lancet Child Adolesc Health. 2019 Jan;3(1):44-54
pubmed: 30446301
Indian J Pharm Sci. 2009 Jan;71(1):1-7
pubmed: 20177448
Cochrane Database Syst Rev. 2009 Jul 08;(3):CD007346
pubmed: 19588425