Whole-Genome Signatures of Selection in Sport Horses Revealed Selection Footprints Related to Musculoskeletal System Development Processes.
horse
musculoskeletal
non-sport
signature of selection
sport
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
26 Dec 2019
26 Dec 2019
Historique:
received:
28
11
2019
revised:
11
12
2019
accepted:
23
12
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
epublish
Résumé
Selective breeding has led to gradual changes at the genome level of horses. Deciphering selective pressure patterns is progressive to understand how breeding strategies have shaped the sport horse genome; although, little is known about the genomic regions under selective pressures in sport horse breeds. The major goal of this study was to shed light on genomic regions and biological pathways under selective pressures in sport horses. In this study, whole-genome sequences of 16 modern sport and 35 non-sport horses were used to investigate the genomic selective signals of sport performance, by employing fixation index, nucleotide diversity, and Tajima's D approaches. A total number of 49 shared genes were identified using these approaches. The functional enrichment analysis for candidate genes revealed novel significant biological processes related to musculoskeletal system development, such as limb development and morphogenesis, having been targeted by selection in sport breeds.
Identifiants
pubmed: 31888018
pii: ani10010053
doi: 10.3390/ani10010053
pmc: PMC7023322
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Anim Genet. 2017 Jun;48(3):287-294
pubmed: 28111759
Nat Rev Genet. 2002 Apr;3(4):299-309
pubmed: 11967554
Development. 2013 Oct;140(19):3951-63
pubmed: 24046316
Am J Vet Res. 2007 Nov;68(11):1232-8
pubmed: 17975979
PLoS Genet. 2013;9(1):e1003211
pubmed: 23349635
PLoS One. 2015 Oct 16;10(10):e0140749
pubmed: 26474182
Bioinformatics. 2011 Aug 1;27(15):2156-8
pubmed: 21653522
PLoS Genet. 2012 Jan;8(1):e1002451
pubmed: 22253606
Genet Mol Res. 2011 Oct 31;10(4):4104-13
pubmed: 22057995
Genetics. 1989 Nov;123(3):585-95
pubmed: 2513255
Genet Sel Evol. 2006 Nov-Dec;38(6):657-71
pubmed: 17129565
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5269-73
pubmed: 291943
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
BMC Genomics. 2019 Sep 18;20(1):717
pubmed: 31533613
Neurogenetics. 2009 Jul;10(3):183-90
pubmed: 19271249
Genome. 2019 Apr;62(4):279-285
pubmed: 30779599
Genes (Basel). 2019 May 14;10(5):
pubmed: 31091839
Genet Mol Biol. 2014 Jun;37(2):330-42
pubmed: 25071397
Curr Osteoporos Rep. 2014 Dec;12(4):420-7
pubmed: 25266923
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4888-91
pubmed: 21383175
PLoS One. 2017 May 2;12(5):e0176780
pubmed: 28463982
BMC Genomics. 2014 Jul 04;15:562
pubmed: 24996778
J Exp Biol. 2005 Jan;208(Pt 2):249-60
pubmed: 15634844
Anat Rec (Hoboken). 2016 Jun;299(6):722-9
pubmed: 26934175
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
PLoS One. 2013;8(1):e54997
pubmed: 23383025
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Anim Genet. 2016 Jun;47(3):370-2
pubmed: 26857482
Bioinformatics. 2017 May 15;33(10):1581-1582
pubmed: 28093408
Asian-Australas J Anim Sci. 2015 Nov;28(11):1525-31
pubmed: 26333666
Bioinformatics. 2019 May 15;35(10):1786-1788
pubmed: 30321304
BMC Genomics. 2018 Jun 25;19(1):492
pubmed: 29940849
Sci Rep. 2017 Nov 9;7(1):15142
pubmed: 29123196
PLoS One. 2019 Jan 30;14(1):e0210751
pubmed: 30699152
Genome Biol Evol. 2015 Dec 03;8(1):42-50
pubmed: 26637467
Sci Rep. 2016 Dec 12;6:38932
pubmed: 27941843
Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19529-36
pubmed: 23151514
PLoS One. 2012;7(7):e39929
pubmed: 22808074
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Vet J. 2011 Oct;190(1):39-48
pubmed: 21115378
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Evolution. 1984 Nov;38(6):1358-1370
pubmed: 28563791
Evol Bioinform Online. 2018 Jun 04;14:1176934318775106
pubmed: 29899660
Mol Biol Evol. 2016 Oct;33(10):2576-92
pubmed: 27401233
PeerJ. 2017 Sep 28;5:e3866
pubmed: 28970972
PLoS One. 2019 Apr 25;14(4):e0215913
pubmed: 31022261
BMC Genomics. 2015 Oct 09;16:764
pubmed: 26452642