Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Ace Card to Address Autoimmune Diseases.
Autoimmune diseases
Exosome
Immunomodulation
Mesenchymal stem cell
Therapeutics
Journal
International journal of stem cells
ISSN: 2005-3606
Titre abrégé: Int J Stem Cells
Pays: Korea (South)
ID NLM: 101497587
Informations de publication
Date de publication:
30 Mar 2020
30 Mar 2020
Historique:
received:
10
09
2019
accepted:
03
11
2019
pubmed:
1
1
2020
medline:
1
1
2020
entrez:
31
12
2019
Statut:
ppublish
Résumé
With the development of novel treatments for autoimmune disorders, it has become a popular research focus which mesenchymal stem cells (MSCs) have the capacity to counteract with autoimmune diseases progression. One of the underlying mechanisms behind their activities is the release of extracellular vesicles especially exosomes. MSC-derived exosomes are hypoimmunogenic nanocarriers which contain numerous immunoregulatory factors and similar to other exosomes, are able to pass through boundaries like the blood-brain barrier (BBB). Accumulating evidence provided by animal studies has demonstrated that MSC-derived exosomes, as a novel therapy, can re-induce self-tolerance, without subsequent complications reported for other treatments. Therefore, therapeutic applications of MSC-derived exosomes are contributing to core advances in the field of autoimmune diseases. Here, we briefly describe the biological characteristics of MSC-derived exosomes and review the experimentally verified outcomes for autoimmune disease therapy purposes.
Identifiants
pubmed: 31887849
pii: ijsc19108
doi: 10.15283/ijsc19108
pmc: PMC7119210
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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