C. elegans expressing D76N β
Amyloid
/ chemistry
Amyloidosis
/ genetics
Animals
Animals, Genetically Modified
Caenorhabditis elegans
/ genetics
Caenorhabditis elegans Proteins
/ metabolism
Disease Models, Animal
Drug Evaluation, Preclinical
/ methods
Mutation, Missense
Phenotype
Protein Aggregation, Pathological
/ prevention & control
Protein Folding
beta 2-Microglobulin
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 12 2019
27 12 2019
Historique:
received:
26
07
2019
accepted:
10
12
2019
entrez:
29
12
2019
pubmed:
29
12
2019
medline:
4
11
2020
Statut:
epublish
Résumé
The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic avenues. The natural human variant of β
Identifiants
pubmed: 31882874
doi: 10.1038/s41598-019-56498-5
pii: 10.1038/s41598-019-56498-5
pmc: PMC6934621
doi:
Substances chimiques
Amyloid
0
Caenorhabditis elegans Proteins
0
beta 2-Microglobulin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19960Subventions
Organisme : Medical Research Council
ID : MR/N024842/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R016984/1
Pays : United Kingdom
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Références
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10417-22
pubmed: 12122205
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9368-72
pubmed: 7568134
J Biol Chem. 2011 Jan 21;286(3):2121-31
pubmed: 21068391
Curr Top Med Chem. 2017;17(18):2067-2076
pubmed: 28137208
Neurobiol Dis. 2010 Nov;40(2):424-31
pubmed: 20637283
Br Med Bull. 1973 Sep;29(3):269-71
pubmed: 4807330
Amyloid. 2010 Jun;17(2):50-62
pubmed: 20462363
Nat Rev Drug Discov. 2006 May;5(5):387-98
pubmed: 16672925
Trends Genet. 2001 Nov;17(11):646-53
pubmed: 11672865
Sci Rep. 2017 Apr 21;7:46711
pubmed: 28429761
PLoS One. 2012;7(12):e52314
pubmed: 23284985
J Biol Chem. 2013 Oct 25;288(43):30917-30
pubmed: 24014031
EMBO Mol Med. 2015 Aug 18;7(10):1337-49
pubmed: 26286619
Sci Adv. 2017 Jun 21;3(6):e1700488
pubmed: 28691099
PLoS Genet. 2008 Mar 21;4(3):e1000027
pubmed: 18369446
J Biol Chem. 2015 Apr 17;290(16):9951-8
pubmed: 25750126
Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7710-E7719
pubmed: 30061394
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Development. 1997 Feb;124(3):637-44
pubmed: 9043078
Mol Neurodegener. 2012 Nov 21;7:57
pubmed: 23171715
Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):8-21
pubmed: 29223747