Chemical composition, Fatty acids profile and Biological properties of Thymus capitatus (L.) Hoffmanns, essential Oil.
Anti-Infective Agents
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemistry
Antioxidants
/ chemistry
Bacteria
/ drug effects
Cell Line
Dose-Response Relationship, Drug
Fatty Acids
/ chemistry
Fungi
/ drug effects
Humans
Microbial Sensitivity Tests
Oils, Volatile
/ analysis
Phytochemicals
/ chemistry
Plant Extracts
/ chemistry
Thymus Plant
/ chemistry
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 12 2019
27 12 2019
Historique:
received:
06
05
2019
accepted:
30
11
2019
entrez:
29
12
2019
pubmed:
29
12
2019
medline:
18
11
2020
Statut:
epublish
Résumé
T. capitatus is widely used in traditional medicine in Tunisia. The main goal of this study was to evaluate the phytochemical composition, the fatty acids profile, the antioxidant, antibacterial, and antifungal activities as well as the cytotoxic potential of the essential oil (EO) of this plant. The identification and the quantification of the different constituents of the tested EO was determined by gas chromatography-mass spectrometry (GC-MS). Antioxidant activities were evaluated by spectrophotometric methods and chemical tests. HCT 116 cells were used to evaluate the cytotoxic effect of the EO. The microdilution method was conducted to evaluate the antibacterial activity. Poisoned food method was used to test the antifungal activities against fungi species such Aspergillus niger and Aspergillus flavus. The EO presented several components, mainly monoterpenes. Results revealed that T. capitatus EO is not cytotoxic and showed excellent antioxidant activity with a dose dependent manner. Regarding antimicrobial activity, T. capitatus EO was efficient against all tested bacteria and fungi.
Identifiants
pubmed: 31882812
doi: 10.1038/s41598-019-56580-y
pii: 10.1038/s41598-019-56580-y
pmc: PMC6934870
doi:
Substances chimiques
Anti-Infective Agents
0
Antineoplastic Agents, Phytogenic
0
Antioxidants
0
Fatty Acids
0
Oils, Volatile
0
Phytochemicals
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20134Références
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