Effects of Half- or Whole-Night Shifts on Physiological and Cognitive Parameters in Women.
Cytokines
Half-night
Hormones
Shift work
Whole-night
Journal
The American journal of the medical sciences
ISSN: 1538-2990
Titre abrégé: Am J Med Sci
Pays: United States
ID NLM: 0370506
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
01
08
2019
revised:
29
11
2019
accepted:
02
12
2019
pubmed:
29
12
2019
medline:
15
12
2020
entrez:
29
12
2019
Statut:
ppublish
Résumé
The study assessed the effects of whole- or half-night shifts on leptin, melatonin, sex hormones, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), IL-6, hematological parameters, sleep quality and attentional performance in women working in the health sector. Women working whole-night shifts (16:00-08:00 hours, n = 20), half-night shifts (16:00-24:00 hours, n = 20) or day shifts (08:00-16:00 hours, n = 20) participated in the study. Blood pressure, respiratory rate, proximal skin temperature (forehead), blood glucose, leptin, melatonin, estradiol, progesterone, IL-1β, TNF-α, and IL-6 concentrations, complete blood count and erythrocyte sedimentation rate (ESR) were measured in the beginning and at the end of the shifts. The participants filled in sleep quality questionnaires and performed visual attention tests. Half- and whole-night shifts caused problems in sleep duration and quality and disturbed the melatonin rhythm. Women working both half- and whole-night shifts had significantly higher nucleated erythrocytes (P = 0.006), eosinophils (P = 0.031), lymphocytes (P = 0.001) and leptin concentrations (P = 0.001) but had lower ESR (P = 0.046) and neutrophil percentage (P = 0.001) than that of day-time workers. Whole-night shifts caused additional changes including lower attentional performance (P = 0.035), lower platelet counts (P = 0.000) and lower estradiol levels (P = 0.029), but higher TNF-α levels (P = 0.000), than the control group. Moreover, whole-night shifts increased IL-1β levels before the shift (P < 0.001) and increased IL-6 levels over the half-night shifts (P < 0.05). Half-night shifts disturbed sleep parameters and the melatonin rhythm, perturbed blood cell turnover and increased leptin levels. Whole-night shifts caused additional problems including suppressed estradiol, activated inflammatory responses and decreased visual attention. All together, the data suggest that night shifts, especially whole-night shifts, should be refrained from or countermeasures should be taken.
Sections du résumé
BACKGROUND
The study assessed the effects of whole- or half-night shifts on leptin, melatonin, sex hormones, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), IL-6, hematological parameters, sleep quality and attentional performance in women working in the health sector.
MATERIALS AND METHODS
Women working whole-night shifts (16:00-08:00 hours, n = 20), half-night shifts (16:00-24:00 hours, n = 20) or day shifts (08:00-16:00 hours, n = 20) participated in the study. Blood pressure, respiratory rate, proximal skin temperature (forehead), blood glucose, leptin, melatonin, estradiol, progesterone, IL-1β, TNF-α, and IL-6 concentrations, complete blood count and erythrocyte sedimentation rate (ESR) were measured in the beginning and at the end of the shifts. The participants filled in sleep quality questionnaires and performed visual attention tests.
RESULTS
Half- and whole-night shifts caused problems in sleep duration and quality and disturbed the melatonin rhythm. Women working both half- and whole-night shifts had significantly higher nucleated erythrocytes (P = 0.006), eosinophils (P = 0.031), lymphocytes (P = 0.001) and leptin concentrations (P = 0.001) but had lower ESR (P = 0.046) and neutrophil percentage (P = 0.001) than that of day-time workers. Whole-night shifts caused additional changes including lower attentional performance (P = 0.035), lower platelet counts (P = 0.000) and lower estradiol levels (P = 0.029), but higher TNF-α levels (P = 0.000), than the control group. Moreover, whole-night shifts increased IL-1β levels before the shift (P < 0.001) and increased IL-6 levels over the half-night shifts (P < 0.05).
CONCLUSIONS
Half-night shifts disturbed sleep parameters and the melatonin rhythm, perturbed blood cell turnover and increased leptin levels. Whole-night shifts caused additional problems including suppressed estradiol, activated inflammatory responses and decreased visual attention. All together, the data suggest that night shifts, especially whole-night shifts, should be refrained from or countermeasures should be taken.
Identifiants
pubmed: 31882159
pii: S0002-9629(19)30426-4
doi: 10.1016/j.amjms.2019.12.002
pii:
doi:
Substances chimiques
Blood Glucose
0
Gonadal Steroid Hormones
0
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
525-536Informations de copyright
Copyright © 2019 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.